SynthesisBMC musculoskeletal disorders2016
The first metatarsophalangeal joint in gout: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Effects of a footwear intervention on foot pain and disability in people with gout: a randomised controlled trial.Arthritis research & therapy · 2019Trial
- Paravertebral crystal deposition disease: a retrospective study of clinical presentation, prevalence, and CT imaging findings.Skeletal radiology · 2025Article
- Exercise and hyperuricemia: an opinion article.Annals of medicine · 2024Article
- Gout arthritis of the ankle successfully treated with arthroscopic debridement: A case report.International journal of surgery case reports · 2024Article
- Single photon emission computed tomography/computed tomography imaging of gouty arthritis: A new voice.Journal of translational internal medicine · 2024Article
- Epidemiology and diagnosis of gout in sub-saharan Africa: a scoping review.BMC rheumatology · 2024Article
- Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases.International journal of plant, animal and environmental sciences · 2024Article
- Orthopaedic Management of Gout.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- High-Resolution Ultrasound of the Forefoot and Common Pathologies.Diagnostics (Basel, Switzerland) · 2022Review
- Prevalence of Monosodium Urate (MSU) Deposits in Cadavers Detected by Dual-Energy Computed Tomography (DECT).Diagnostics (Basel, Switzerland) · 2022Article
- Association between serum uric acid levels and colonic diverticulosis in terms of sex.PloS one · 2022Article
- Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced Interleukin-1The Journal of pharmacology and experimental therapeutics · 2021Article
- Article
- Treatment of atypical gouty arthritis of the hip using total hip arthroplasty: A case report.Medicine · 2020Article
- Injection Techniques for Common Chronic Pain Conditions of the Foot: A Comprehensive Review.Pain and therapy · 2020Review
- Association Between Gout and Injury Risk: A National Retrospective Cohort Study.International journal of environmental research and public health · 2020Article
- CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout.Scientific reports · 2020Article
- Design and Biological Evaluation of Colchicine-CD44-Targeted Peptide Conjugate in an In Vitro Model of Crystal Induced Inflammation.Molecules (Basel, Switzerland) · 2019Article
- Demographic, clinical, and laboratory features of Turkish patients with gouty arthritis: A prospective cohort study.European journal of rheumatology · 2019Article
- Foot structure, pain and functional ability in people with gout in primary care: cross-sectional findings from the Clinical Assessment Study of the Foot.Journal of foot and ankle research · 2019Observational
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this review was to qualitatively synthesise studies that have investigated characteristics of the first metatarsophalangeal joint (1(st) MTP) in gout and to undertake a meta-analysis to estimate the average prevalence of acute 1(st) MTP arthritis across studies in people with gout.
methodsStudies published in English were included if they involved participants who had a diagnosis of gout and presented original findings relating to the following outcome measures associated with the 1(st) MTP: epidemiology; clinical features; structural and functional characteristics; and microscopic and imaging features.
resultsForty-five studies were included in the qualitative synthesis. 1(st) MTP pain was a prominent feature in people with gout. People with 1(st) MTP gout reported walking- and general-disability. Structural and functional characteristics of 1(st) MTP gout included hallux valgus, osteoarthritis, and restricted joint motion. Successful crystal aspiration ranged from 81 to 91 % and positive crystal identification via microscopy ranged from 83 to 93 % in patients with a history of 1(st) MTP gout. Imaging features were common at the 1(st) MTP including the double contour sign, tophi and erosions. Eleven studies involving 2,325 participants were included in the meta-analysis, providing an estimate of the average prevalence of acute 1(st) MTP arthritis across studies of 73 % (95 % prediction interval 40-92 %; range 48-97 %; I(2) = 93 %).
conclusions1(st) MTP acute arthritis is highly prevalent in people with gout and has a substantial impact on patient-reported pain and disability. Gout affects the structure and function of the 1(st) MTP. Microscopic and imaging studies have demonstrated crystal deposition and joint damage at the 1(st) MTP in people with gout.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.