Evidence map›Paper›PMID 26864741›Full record

ArticleThe journal of family planning and reproductive health care2016

Dual contraceptive method use in HIV-serodiscordant Kenyan couples.

Alison C Roxby, Leïla Ben-Youssef, Grace Marx, Freda Kinoti, Rose Bosire, Brandon Guthrie, Romel Mackelprang, James Kiarie, Grace John-Stewart, Carey Farquhar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of family planning and reproductive health care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Alison C RoxbyAssistant Professor, Departments of Medicine and Global Health, University of Washington, WA, USA.
Leïla Ben-YoussefResident Physician, Department of Emergency Medicine, Alameda County Medical Center, Highland Hospital, Oakland, CA, USA, and University of Washington School of Medicine, WA, USA.
Grace MarxPhysician, Kenya Medical Research Institute, Nairobi, Kenya.
Freda KinotiSenior Clinical Research Scientist, Kenya Medical Research Institute, Nairobi, Kenya.
Rose BosireSenior Clinical Research Scientist, Kenya Medical Research Institute, Nairobi, Kenya.
Brandon GuthrieAssistant Professor, Departments of Medicine and Global Health, University of Washington, WA, USA.
Romel MackelprangAssistant Professor, Departments of Epidemiology and Global Health, University of Washington, Seattle WA, USA.
James KiarieActing Instructor, Department of Global Health, University of Washington, Seattle, WA, USA.
Grace John-StewartAssistant Professor, Departments of Medicine and Global Health, University of Washington, WA, USA.
Carey FarquharAssistant Professor, Departments of Medicine and Global Health, University of Washington, WA, USA.
University of Washington · USKenya Medical Research Institute · KEAlameda Health System · USUniversity of Nairobi · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Protective cellular immune responses in HIV-1 discordant couplesR01AI068431 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2006 to 2010
$3.1M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Immune activation during pregnancy and contraception in HIV-infected Kenyan womenK23HD071788 · NICHD · UNIVERSITY OF WASHINGTON · PI ROXBY, ALISON CHRISTINA · 2012 to 2016
$648k
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
Overcoming Barriers to HIV/AIDS Care and ART InitiationK01AI098527 · NIAID · UNIVERSITY OF WASHINGTON · PI GUTHRIE, BRANDON LODGE · 2012 to 2016
$647k
CLINICAL AND MOLECULAR STUDIES OF DRUG-RESISTANT MALARIAK01TW000007 · FIC · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI DORSEY, MATTHEW G · 1999 to 2005
$513k
FIC NIH HHS D43 TW000007FIC NIH HHS K01 TW000007FIC NIH HHS R24 TW007988NIAID NIH HHS K01 AI098527NIAID NIH HHS K24 AI087399NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI068431NICHD NIH HHS K23 HD071788NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412
6 · The paper itself

Abstract

backgroundWorld Health Organization (WHO) guidelines recommend dual contraceptive method use with condoms and another contraceptive to reduce both incidence of HIV/sexually transmitted infection transmission and unintended pregnancies. This qualitative study assessed the barriers to and motivations for dual contraceptive use in Kenyan HIV-serodiscordant couples.

methodsHIV-serodiscordant couples in Nairobi, Kenya, were recruited from two longitudinal cohorts. Qualitative semistructured interviews were conducted using a semistructured questionnaire. Twelve male and 12 female members of serodiscordant couples and 10 women with incident pregnancies during the cohort studies were included.

resultsFew couples reported using dual contraceptive methods, with men reporting more condom use than women. No HIV-seropositive men or HIV-seronegative women reported using non-condom contraception. Men and women agreed that men play a dominant role in decisions to use both condoms and contraception in HIV-serodiscordant couples. Participants reported that perceptions of side effects, male partner preference, and reproductive desire were critical factors in contraceptive decisions. Both men and women saw dual contraceptive method use as redundant and a sign of possible unfaithfulness. Many participants actively desired pregnancy, but few were able to accurately define monthly fertility windows.

conclusionsDual contraceptive method use was low in these HIV-serodiscordant couples, with some couples finding it unnecessary while using condoms, and others being more focused on conceiving a child. Biomedical HIV prevention, including male circumcision, pre-exposure prophylaxis or antiretroviral therapy to reduce HIV transmission, may be more acceptable strategies to promote safer sexual relations among HIV-serodiscordant couples and safer conception when desired.

Indexed as

condomcounsellinghuman immunodeficiency virusqualitative researchsexually transmitted infections

Identifiers

PMID26864741
PMCPMC4980270
OpenAlexW2304518168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.