ArticleNature communications2016
Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The Drosophila DEG/ENaC PPK12 is a NaScientific reports · 2025Article
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- Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila.Communications biology · 2025Article
- Sensory discrimination of chemical and temperature stimuli in the acoel Symsagittifera roscoffensis.PloS one · 2025Article
- Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.PLoS biology · 2025Article
- The texture-taste connection: Multimodal sensory neurons in fly larvae.PLoS biology · 2025Article
- Article
- Gustation in insects: taste qualities and types of evidence used to show taste function of specific body parts.Journal of insect science (Online) · 2023Article
- An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.Nature communications · 2023Article
- Systematic analysis reveals novel insight into the molecular determinants of function, diversity and evolution of sweet taste receptors T1R2/T1R3 in primates.Frontiers in molecular biosciences · 2023Article
- The chemosensory system of theFly · 2022Review
- Taste sensing and sugar detection mechanisms ineLife · 2021Article
- Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis.Science advances · 2021Article
- The Structure and Function of Ionotropic Receptors inFrontiers in molecular neuroscience · 2020Review
- In vivo assembly and trafficking of olfactory Ionotropic Receptors.BMC biology · 2019Article
- Physiological responses of insects to microbial fermentation products: Insights from the interactions between Drosophila and acetic acid.Journal of insect physiology · 2018Article
- Membrane Proteins Mediating Reception and Transduction in Chemosensory Neurons in Mosquitoes.Frontiers in physiology · 2018Review
- Molecular and Cellular Organization of Taste Neurons in Adult Drosophila Pharynx.Cell reports · 2017Article
- A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste.PLoS genetics · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs of Drosophila larvae employ a surprisingly different mode of gustatory information coding. Using a novel method for calcium imaging in the larval gustatory system, we identify a multimodal GRN that responds to chemicals of different taste modalities with opposing valence, such as sweet sucrose and bitter denatonium, reliant on different sensory receptors. This multimodal neuron is essential for bitter compound avoidance, and its artificial activation is sufficient to mediate aversion. However, the neuron is also essential for the integration of taste blends. Our findings support a model for taste coding in larvae, in which distinct receptor proteins mediate different responses within the same, multimodal GRN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.