ArticleScientific reports2016
A Mendelian randomization study of testosterone and cognition in men.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies.Journal of Alzheimer's disease : JAD · 2018Pooled it
- Editorial: Unpacking the Link between Income, Smoking, and Dementia Risk: Insights and Opportunities.JMA journal · 2025Article
- Among men, androgens are associated with a decrease in Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Associations of Bioavailable Serum Testosterone With Cognitive Function in Older Men: Results From the National Health and Nutrition Examination Survey.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Genetic Variation and Mendelian Randomization Approaches.Advances in experimental medicine and biology · 2022Article
- Sex-specific genetic effects across biomarkers.European journal of human genetics : EJHG · 2021Article
- Low Serum Testosterone Concentrations Are Associated With Poor Cognitive Performance in Older Men but Not Women.Frontiers in aging neuroscience · 2021Article
- The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study.Genes · 2020Article
- Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated withJournal of traditional and complementary medicine · 2018Article
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- Using redescription mining to relate clinical and biological characteristics of cognitively impaired and Alzheimer's disease patients.PloS one · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone replacement for older men is increasingly common, with some observations suggesting a protective effect on cognitive function. We examined the association of endogenous testosterone with cognitive function among older men in a Mendelian randomization study using a separate-sample instrumental variable (SSIV) analysis estimator to minimize confounding and reverse causality. A genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong, based on selected testosterone-related single nucleotide polymorphisms (rs10046, rs1008805 and rs1256031). The association of genetically predicted testosterone with delayed 10-word recall score and Mini-Mental State Examination (MMSE) score was assessed at baseline and follow-up using generalized estimating equation among 4,212 older Chinese men from the Guangzhou Biobank Cohort Study. Predicted testosterone was not associated with delayed 10-word recall score (-0.02 per nmol/L testosterone, 95% confidence interval (CI) -0.06-0.02) or MMSE score (0.06, 95% CI -0.002-0.12). These estimates were similar after additional adjustment for age, education, smoking, use of alcohol, body mass index and the Framingham score. Our findings do not corroborate observed protective effects of testosterone on cognitive function among older men.
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