ArticleBMC medical imaging2016
Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data.
Article in BMC medical imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Radiomics approach for identifying radiation-induced normal tissue toxicity in the lung.Scientific reports · 2024Article
- Radiomics and Radiogenomics in Preclinical Imaging on Murine Models: A Narrative Review.Journal of personalized medicine · 2023Review
- Prospects and Challenges of Radiomics by Using Nononcologic Routine Chest CT.Radiology. Cardiothoracic imaging · 2020Review
- A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19.Frontiers in immunology · 2020Review
- Fractal-based radiomic approach to predict complete pathological response after chemo-radiotherapy in rectal cancer.La Radiologia medica · 2018Article
- Novel radiomics evaluation of bone formation utilizing multimodal (SPECT/X-ray CT) in vivo imaging.PloS one · 2018Article
- Towards precision medicine: from quantitative imaging to radiomics.Journal of Zhejiang University. Science. BReview
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung diseases (resulting from air pollution) require a widely accessible method for risk estimation and early diagnosis to ensure proper and responsive treatment. Radiomics-based fractal dimension analysis of X-ray computed tomography attenuation patterns in chest voxels of mice exposed to different air polluting agents was performed to model early stages of disease and establish differential diagnosis.
methodsTo model different types of air pollution, BALBc/ByJ mouse groups were exposed to cigarette smoke combined with ozone, sulphur dioxide gas and a control group was established. Two weeks after exposure, the frequency distributions of image voxel attenuation data were evaluated. Specific cut-off ranges were defined to group voxels by attenuation. Cut-off ranges were binarized and their spatial pattern was associated with calculated fractal dimension, then abstracted by the fractal dimension -- cut-off range mathematical function. Nonparametric Kruskal-Wallis (KW) and Mann-Whitney post hoc (MWph) tests were used.
resultsEach cut-off range versus fractal dimension function plot was found to contain two distinctive Gaussian curves. The ratios of the Gaussian curve parameters are considerably significant and are statistically distinguishable within the three exposure groups.
conclusionsA new radiomics evaluation method was established based on analysis of the fractal dimension of chest X-ray computed tomography data segments. The specific attenuation patterns calculated utilizing our method may diagnose and monitor certain lung diseases, such as chronic obstructive pulmonary disease (COPD), asthma, tuberculosis or lung carcinomas.
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