Trial reportThe American journal of clinical nutrition2016
Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00272428 (The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Dose-Response Association of Dietary Inflammatory Potential with All-Cause and Cause-Specific Mortality.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes.International journal of cancer · 2017Pooled it
- Pooled it
- Inflammatory potential of diet and risk of cardiovascular disease or mortality: A meta-analysis.Scientific reports · 2017Pooled it
- The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults.The Journal of nutrition · 2018Trial
- Inverse association between dietary antioxidant indices and dietary inflammatory potential in jordanian adults: a cross-sectional study.Journal of health, population, and nutrition · 2026Article
- Association between oxidative balance score and osteosarcopenia in US adults: insights from a population-based study.Frontiers in nutrition · 2025Article
- Inflammatory potential of diet and mortality in Australian adults.Public health nutrition · 2024Article
- Associations between dietary inflammatory index and stroke risk: based on NHANES 2005-2018.Scientific reports · 2024Article
- Association of Pro-Inflammatory Diet with Long-Term Risk of All-Cause and Cardiovascular Disease Mortality: NIPPON DATA80.Journal of atherosclerosis and thrombosis · 2024Article
- Association between the dietary inflammatory index and all-cause mortality in the U.S. cancer survivors: A prospective cohort study using the National Health and Nutrition Examination Survey database.Preventive medicine reports · 2024Article
- Correlation between dietary inflammation and mortality among hyperlipidemics.Lipids in health and disease · 2023Article
- Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor-infiltrating lymphocyte levels.Clinical and translational medicine · 2022Article
- Association Between Dietary Intakes and Plaque Vulnerability Measured by Optical Coherence Tomography in Patients With Coronary Heart Disease: A Mediation Analysis of Inflammatory Factors.Frontiers in nutrition · 2022Article
- Association between Dietary Inflammatory Index and kidney stones in US adults: data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016.Public health nutrition · 2021Article
- Article
- Inflammatory Potential of the Diet and Incidence of Crohn's Disease and Ulcerative Colitis in the EPIC-Spain Cohort.Nutrients · 2021Article
- Novel Dietary and Lifestyle Inflammation Scores Directly Associated with All-Cause, All-Cancer, and All-Cardiovascular Disease Mortality Risks Among Women.The Journal of nutrition · 2021Article
- Greater Dietary Inflammatory Potential Is Associated With Higher Likelihood of Abdominal Aortic Calcification.Frontiers in cardiovascular medicine · 2021Article
- A Higher Dietary Inflammatory Index Score is Associated with a Higher Risk of Incidence and Mortality of Cancer: A Comprehensive Systematic Review and Meta-Analysis.International journal of preventive medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundChronic inflammation is a central mechanism involved in cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases, 4 leading causes of mortality. Diet is a major source of pro- and anti-inflammatory bioactive compounds. The Dietary Inflammatory Index (DII) was designed to estimate the overall inflammatory potential of the diet.
objectiveOur aim was to study the prospective association between the DII and mortality, as well as assess whether antioxidant supplementation could modulate this association.
designThe Supplémentation en Vitamines et Minéraux Antioxydants study was a randomized, double-blind, placebo-controlled trial in which participants received low-dose antioxidants or a placebo from 1994 to 2002. In this observational prospective analysis, 8089 participants (mean ± SD age at baseline: 49.0 ± 6.3 y) were followed between 1994 and 2007 (median: 12.4 y). The DII was calculated from repeated 24-h dietary records; higher scores correspond to more proinflammatory diets. A total of 207 deaths occurred during follow-up, including 123 due to cancer and 41 due to cardiovascular events. Multivariate Cox proportional hazards models were computed.
resultsSex-specific tertiles of the DII were positively associated with cardiovascular + cancer mortality (HR for tertile 3 compared with tertile 1 = 1.53; 95% CI: 1.01, 2.32; P-trend = 0.05) and specific cancer mortality (HR for tertile 3 compared with tertile 1 = 1.83; 95% CI: 1.12, 2.99; P-trend = 0.02). The corresponding P value was 0.07 for all-cause mortality. The DII was statistically significantly associated with increased all-cause mortality in the placebo group (HR for tertile 3 compared with tertile 1 = 2.10; 95% CI: 1.15, 3.84; P-trend = 0.02) but not in the antioxidant-supplemented group (P-trend = 0.8; P-interaction = 0.098).
conclusionThese results suggest that a proinflammatory diet is associated with increased all-cause and cancer mortality and antioxidants may counteract some of the proinflammatory effects of the diet. This trial was registered at clinicaltrials.gov as NCT00272428.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.