ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2015
Label-free proteomic analysis of the hydrophobic membrane protein complement in articular chondrocytes: a technique for identification of membrane biomarkers.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Cell Partitioning Design for Microfluidic ATPS Devices: A Dynamic Energy Strategy and Calculation Using Chondrocytes and Model Microparticles.Micromachines · 2025Article
- The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis.Frontiers in immunology · 2023Article
- Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy.The American journal of sports medicine · 2021Article
- Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines.BMC molecular and cell biology · 2020Article
- Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis.Scientific reports · 2019Article
- Biomarkers of (osteo)arthritis.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
contextThere is insufficient knowledge about the chondrocyte membranome and its molecular composition.
objectiveTo develop a Triton X-114 based separation technique using nanoLC-MS/MS combined with shotgun proteomics to identify chondrocyte membrane proteins. MATERIALS AND
methodsArticular chondrocytes from equine metacarpophalangeal joints were separated into hydrophobic and hydrophilic fractions; trypsin-digested proteins were analysed by nanoLC-MS/MS.
resultsA total of 315 proteins were identified. The phase extraction method yielded a high proportion of membrane proteins (56%) including CD276, S100-A6 and three VDAC isoforms. DISCUSSION: Defining the chondrocyte membranome is likely to reveal new biomarker targets for conventional and biological drug discovery.
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Registered trials
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