Evidence map›Paper›PMID 26864126›Full record

SynthesisHuman vaccines & immunotherapeutics2016

Tempest in a teapot: A systematic review of HPV vaccination and risk compensation research.

Monica L Kasting, Gilla K Shapiro, Zeev Rosberger, Jessica A Kahn, Gregory D Zimet

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monica L Kastinga Indiana University School of Public Health , Department of Epidemiology , Indianapolis , IN , USA.
Gilla K Shapirob Department of Psychology , McGill University , Montreal , QC , Canada.
Zeev Rosbergerb Department of Psychology , McGill University , Montreal , QC , Canada.
Jessica A Kahnd Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine , Cincinnati , OH , USA.
Gregory D Zimete Indiana University School of Medicine, Section of Adolescent Medicine , Indianapolis , IN , USA.

Funding

Training in Research for Behavioral Oncology and Cancer Control ProgramR25CA117865 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2006 to 2015
$4.1M
Interdisciplinary Training in Cancer Prevention and ControlT32CA117865 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Victoria Lee Champion, Catherine E Mosher · 2016 to 2026
$2.4M
NCI NIH HHS R25 CA117865NCI NIH HHS T32 CA117865
6 · The paper itself

Abstract

There has been some concern among parents and in the media that vaccinating children against human papillomavirus could be seen as giving children permission to engage in risky sexual behaviors (also known as sexual disinhibition). Several studies have found this concern to be unfounded but there have been no attempts to synthesize the relevant studies in order to assess if there is evidence of sexual disinhibition. The aim of this study was to synthesize recent literature examining sexual behaviors and biological outcomes (e.g., sexually transmitted infections) post-HPV vaccination. We reviewed literature from January 1, 2008-June 30, 2015 using PubMed, CINAHL, and Embase with the following search terms: [(sex behavior OR sex behavior OR sexual) AND (human papillomavirus OR HPV) AND (vaccines OR vaccine OR vaccination)] followed by a cited reference search. We included studies that examined biological outcomes and reported behaviors post-vaccination in both males and females. Studies were reviewed by title and abstract and relevant studies were examined as full-text articles. We identified 2,503 articles and 20 were eventually included in the review. None of the studies of sexual behaviors and/or biological outcomes found evidence of riskier behaviors or higher rates of STIs after HPV vaccination. Instead, the studies found that vaccinated compared to unvaccinated individuals were less likely to report vaginal intercourse without a condom (OR = 0.5; 95%CI = 0.4-0.6) and non-use of contraception (OR = 0.27; 95%CI = 0.15-0.48) and unvaccinated participants had higher rates of Chlamydia (OR = 2.3; 95%CI = 1.06-5.00). These results should be reassuring to parents and health care providers.

Indexed as

Risk-TakingSexual BehaviorFemaleHumansIncidenceMalePapillomavirus VaccinesSexually Transmitted DiseasesVaccinationPapillomavirus VaccinesadolescentbehaviorHPV vaccinationinfectious diseasepediatricsrisk compensationsexual disinhibition

Identifiers

PMID26864126
PMCPMC4964724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.