ArticleScientific reports2016
Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026Review
- Evaluation of Burn Depth using Indocyanine Green: Discrepancies Between Macroscopic Visualization and the Microenvironment.Plastic and reconstructive surgery · 2026Article
- [Indicative effect of indocyanine green-near-infrared fluorescence imaging in the thickness of necrotic dermal tissue in porcine burn wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Indocyanine green angiography processing and analysis pipeline for the assessment of indeterminate burn wounds.Journal of biomedical optics · 2025Article
- Inadequacies in uveitis: misnomers, incongruencies, persistence of obsolete terminologies & inappropriate guidelines, treatment inadequacies, and misinterpretations.Journal of ophthalmic inflammation and infection · 2025Review
- Mechanisms of delayed indocyanine green fluorescence and applications to clinical disease processes.Surgery · 2024Review
- Advanced technique of myocardial no-reflow quantification using indocyanine green.Biomedical optics express · 2024Article
- MRI-guided photothermal/photodynamic immune activation combined with PD-1 inhibitor for the multimodal combination therapy of melanoma and metastases.Regenerative biomaterials · 2024Article
- Article
- A Hybrid Imaging Platform(CT/PET/FMI) for Evaluating Tumor Necrosis and Apoptosis in Real-Time.Frontiers in oncology · 2022Article
- A novel multimodal nanoplatform for targeting tumor necrosis.RSC advances · 2021Article
- Real-time visualization of intratumoral necrosis using split-luciferase reconstitution by protein trans-splicing.Molecular therapy oncolytics · 2021Article
- Indeterminate-Depth Burn Injury-Exploring the Uncertainty.The Journal of surgical research · 2020Review
- Updated developments on molecular imaging and therapeutic strategies directed against necrosis.Acta pharmaceutica Sinica. B · 2019Article
- Fluorescent contrast agents for tumor surgery.Experimental and therapeutic medicine · 2018Review
- Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time.Biomedical optics express · 2018Article
- Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging.Biomedical optics express · 2018Article
- Article
- Lasing in blood.Optica · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue necrosis commonly accompanies the development of a wide range of serious diseases. Therefore, highly sensitive detection and precise boundary delineation of necrotic tissue via effective imaging techniques are crucial for clinical treatments; however, no imaging modalities have achieved satisfactory results to date. Although fluorescence molecular imaging (FMI) shows potential in this regard, no effective necrosis-avid fluorescent probe has been developed for clinical applications. Here, we demonstrate that indocyanine green (ICG) can achieve high avidity of necrotic tissue owing to its interaction with lipoprotein (LP) and phospholipids. The mechanism was explored at the cellular and molecular levels through a series of in vitro studies. Detection of necrotic tissue and real-time image-guided surgery were successfully achieved in different organs of different animal models with the help of FMI using in house-designed imaging devices. The results indicated that necrotic tissue with a 0.6 mm diameter could be effectively detected with precise boundary definition. We believe that the new discovery and the associated imaging techniques will improve personalized and precise surgery in the near future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.