ArticleJournal of immunology (Baltimore, Md. : 1950)2016
Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Natural killer cell effector function is critical for host defense against alcohol-associated bacterial pneumonia.NPJ biofilms and microbiomes · 2024Article
- Regulation of Natural Killer Cell TGF-β and AhR Signaling Pathways Via the Intestinal Microbiota is Critical for Host Defense Against Alcohol-Associated Bacterial Pneumonia.Research square · 2023Article
- Article
- ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia.International journal of molecular sciences · 2022Article
- Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia.Communications biology · 2021Article
- Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function.Alcoholism, clinical and experimental research · 2021Article
- Gut Microbiota Modulation as a Potential Target for the Treatment of Lung Infections.Frontiers in pharmacology · 2021Review
- The trophic life cycle stage of Pneumocystis species induces protective adaptive responses without inflammation-mediated progression to pneumonia.Medical mycology · 2018Article
- The respiratory tract microbial biogeography in alcohol use disorder.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae.PLoS pathogens · 2017Article
- Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi.Mediators of inflammation · 2017Review
- CD4(+) T-Cell-Independent Secondary Immune Responses to Pneumocystis Pneumonia.Frontiers in immunology · 2016Article
- Vaccine development for pathogenic fungi: current status and future directions.Expert review of vaccinesReview
- Analysis of the intestinal microbial community and inferred functional capacities during the host response to Pneumocystis pneumonia.Experimental lung researchArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Pneumocystis pneumonia is a major cause of morbidity and mortality in immunocompromised patients, particularly those infected with HIV. In this study, we evaluated the potential of oral immunization with live Pneumocystis to elicit protection against respiratory infection with Pneumocystis murina. C57BL/6 mice vaccinated with live P. murina using a prime-boost vaccination strategy were protected from a subsequent lung challenge with P. murina at 2, 7, 14, and 28 d postinfection even after CD4(+) T cell depletion. Specifically, vaccinated immunocompetent mice had significantly faster clearance than unvaccinated immunocompetent mice and unvaccinated CD4-depleted mice remained persistently infected with P. murina. Vaccination also increased numbers of CD4(+) T cells, CD8(+) T cells, CD19(+) B cells, and CD11b(+) macrophages in the lungs following respiratory infection. In addition, levels of lung, serum, and fecal P. murina-specific IgG and IgA were increased in vaccinated animals. Furthermore, administration of serum from vaccinated mice significantly reduced Pneumocystis lung burden in infected animals compared with control serum. We also found that the diversity of the intestinal microbial community was altered by oral immunization with P. murina. To our knowledge, our data demonstrate for the first time that an oral vaccination strategy prevents Pneumocystis infection.
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Registered trials
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