Evidence map›Paper›PMID 26863570›Full record

ArticleOncotarget2016

Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.

Xiaobo Guo, Ziguo Yang, Qiaoming Zhi, Dan Wang, Lei Guo, Guimei Li, Ruizhen Miao, Yulong Shi, Yuting Kuang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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  9. PDLIM2: Signaling pathways and functions in cancer suppression and host immunity.Biochimica et biophysica acta. Reviews on cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xiaobo GuoDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Ziguo YangDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Qiaoming ZhiDepartments of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Dan WangDepartments of Science and Education, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Lei GuoDepartment of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Guimei LiDepartment of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Ruizhen MiaoDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Yulong ShiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Yuting KuangDepartments of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Shandong Provincial Hospital · CNSoochow University · CNEastern Hepatobiliary Surgery Hospital · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of long noncoding RNAs (lncRNAs) to metastasis of gastric cancer remains largely unknown. We used microarray analysis to identify lncRNAs differentially expressed between normal gastric tissues and gastric cancer tissues and validated these differences in quantitative real-time (qRT)-PCR experiments. The expression levels of lncRNA olfactory receptor, family 3, subfamily A, member 4 (OR3A4) were significantly associated with lymphatic metastasis, the depth of cancer invasion, and distal metastasis in 130 paired gastric cancer tissues. The effects of OR3A4 were assessed by overexpressing and silencing OR3A4 in gastric cancer cells. OR3A4 promoted cancer cell growth, angiogenesis, metastasis, and tumorigenesis in vitro and in vivo. Global microarray analysis combined with RT-PCR, RNA immunoprecipitation, and RNA pull-down analyses after OR3A4 transfection demonstrated that OR3A4 influenced biologic functions in gastric cancer cells via regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1. Our results reveal OR3A4 as an oncogenic lncRNA that promotes tumor progression, Therefore, lncRNAs might function as key regulatory hubs in gastric cancer progression.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAnimalsCarcinogenesisCell LineCell Line, TumorFemaleGene Expression ProfilingHEK293 CellsHumansLIM Domain ProteinsMaleMice, Inbred BALB CMice, NudeMicrofilament ProteinsLIM Domain ProteinsMACC1 protein, humanMicrofilament ProteinsNeoplasm ProteinsNetrinsNTN4 protein, humanPDLIM2 protein, humanRACK1 protein, humanReceptors for Activated C KinaseRNA, Long NoncodingTrans-ActivatorsTranscription Factorsgastric cancerlncRNAmetastasisOR3A4tumorigenesis

Identifiers

PMID26863570
PMCPMC5058680
OpenAlexW2272679700

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.