ArticlePloS one2016
Metabolomic and Transcriptomic Comparison of Solid-State and Submerged Fermentation of Penicillium expansum KACC 40815.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
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- Characterization of Secondary Metabolites from the Co-culture of Trichotomospora Caesia AC-1134 and Streptoverticillium sp. AC-1375 and Evaluation of its Antioxidant Properties.Current microbiology · 2026Article
- Combined analysis of proteomics and metabolism reveals critical roles of oxidoreductase activity in mushrooms stimulated by wolfberry and sea buckthorn substrates.Frontiers in nutrition · 2025Article
- Transcriptomic Approach Reveals Contrasting Patterns of Differential Gene Expression during Tannin Biodegredation byInternational journal of molecular sciences · 2024Article
- Integrated transcriptome and metabolism unravel critical roles of carbon metabolism and oxidoreductase in mushroom with Korshinsk peashrub substrates.BMC genomics · 2024Article
- Antibiofilm activity from endophyte bacteria, Vibrio cholerae strains, and actinomycetes isolates in liquid and solid culture.BMC microbiology · 2023Article
- Complementary Strategies to Unlock Biosynthesis Gene Clusters Encoding Secondary Metabolites in the Filamentous FungusJournal of fungi (Basel, Switzerland) · 2022Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- A comparative GC-MS analysis of bioactive secondary metabolites produced by halotolerant Bacillus spp. isolated from the Great Sebkha of Oran.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Metabolomic profiling, biological evaluation ofRSC advances · 2021Article
- CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster inFrontiers in microbiology · 2021Article
- Penicillium expansum: biology, omics, and management tools for a global postharvest pathogen causing blue mould of pome fruit.Molecular plant pathology · 2020Review
- Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi.Marine drugs · 2020Article
- Integrated Metabolomics and Transcriptomics Unravel the Metabolic Pathway Variations for Different Sized Beech Mushrooms.International journal of molecular sciences · 2019Article
- Comprehensive Secondary Metabolite Profiling Toward Delineating the Solid and Submerged-State Fermentation ofFrontiers in microbiology · 2018Article
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5 authors.
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Abstract
Penicillium spp. are known to harbor a wide array of secondary metabolites with cryptic bioactivities. However, the metabolomics of these species is not well-understood in terms of different fermentation models and conditions. The present study involved metabolomics profiling and transcriptomic analysis of Penicillium expansum 40815 under solid-state fermentation (SSF) and submerged fermentation (SmF). Metabolite profiling was carried out using ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry with multivariate analysis, followed by transcriptomic analyses of differentially expressed genes. In principal component analysis, the metabolite profiling data was studied under different experimental sets, including SSF and SmF. The significantly different metabolites such as polyketide metabolites (agonodepside B, rotiorin, verrucosidin, and ochrephilone) and corresponding gene transcripts (polyketide synthase, aromatic prenyltransferase, and terpenoid synthase) were primarily detected under SmF conditions. In contrast, the meroterpenoid compounds (andrastin A and C) and their genes transcripts were exclusively detected under SSF conditions. We demonstrated that the metabolite production and its corresponding gene expression levels in P. expansum 40815 were significantly influenced by the varying growth parameters and the immediate environment. This study further provides a foundation to produce specific metabolites by regulating fermentation conditions.
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