ArticlePloS one2016
High-Field MRI Reveals a Drastic Increase of Hypoxia-Induced Microhemorrhages upon Tissue Reoxygenation in the Mouse Brain with Strong Predominance in the Olfactory Bulb.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience.Frontiers in aging neuroscience · 2025Review
- Exaggerated hypoxic vascular breakdown in aged brain due to reduced microglial vasculo-protection.Aging cell · 2022Article
- Transcellular blood-brain barrier disruption in malaria-induced reversible brain edema.Life science alliance · 2022Article
- Study of high-altitude cerebral edema using multimodal imaging.Frontiers in neurology · 2022Article
- A Magnetic Resonance-Relaxometry-Based Technique to Identify Blood Products in Brain Parenchyma: An Experimental Study on a Rabbit Model.Frontiers in veterinary science · 2022Article
- Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench.Aging and disease · 2021Review
- Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?Stroke and vascular neurology · 2020Observational
- Mountain sickness with delayed signal changes in the corpus callosum on magnetic resonance imaging: a case report.Journal of rural medicine : JRM · 2019Article
- Complete Restitution of the Ischemic Penumbra after Successful Thrombectomy : A Pilot Study Using Quantitative MRI.Clinical neuroradiology · 2019Article
- Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats.Journal of visualized experiments : JoVE · 2018Article
- Early oxygen therapy does not protect the brain from vasogenic edema following acute ischemic stroke in adult male rats.Scientific reports · 2017Article
- NLR-Dependent Regulation of Inflammation in Multiple Sclerosis.Frontiers in immunology · 2017Review
- A murine model of inflammation-induced cerebral microbleeds.Journal of neuroinflammation · 2016Article
- Development of Cerebral Microbleeds in the APP23-Transgenic Mouse Model of Cerebral Amyloid Angiopathy-A 9.4 Tesla MRI Study.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human pathophysiology of high altitude hypoxic brain injury is not well understood and research on the underlying mechanisms is hampered by the lack of well-characterized animal models. In this study, we explored the evolution of brain injury by magnetic resonance imaging (MRI) and histological methods in mice exposed to normobaric hypoxia at 8% oxygen for 48 hours followed by rapid reoxygenation and incubation for further 24 h under normoxic conditions. T2*-, diffusion-weighted and T2-relaxometry MRI was performed before exposure, immediately after 48 hours of hypoxia and 24 hours after reoxygenation. Cerebral microhemorrhages, previously described in humans suffering from severe high altitude cerebral edema, were also detected in mice upon hypoxia-reoxygenation with a strong region-specific clustering in the olfactory bulb, and to a lesser extent, in the basal ganglia and cerebral white matter. The number of microhemorrhages determined immediately after hypoxia was low, but strongly increased 24 hours upon onset of reoxygenation. Histologically verified microhemorrhages were exclusively located around cerebral microvessels with disrupted interendothelial tight junction protein ZO-1. In contrast, quantitative T2 and apparent-diffusion-coefficient values immediately after hypoxia and after 24 hours of reoxygenation did not show any region-specific alteration, consistent with subtle multifocal but not with regional or global brain edema.
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