ReviewBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2015
Detecting early stage osteoarthritis by optical coherence tomography?
Review in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Evaluation of Engineered Cartilage Composition and Function Using Raman Spectroscopy.Advanced healthcare materials · 2025Article
- Comparison of Bioelectrical Impedance Parameters in Patients With Knee Osteoarthritis: A Case-Control Study.Cureus · 2025Article
- Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences, and Future Directions.Journal of clinical medicine · 2025Review
- Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.Journal of translational medicine · 2024Article
- Impact of experimental setup parameters on the measurement of articular cartilage optical properties in the visible and short near-infrared spectral bands.Biomedical optics express · 2023Article
- Multimodal fluorescence lifetime imaging and optical coherence tomography for longitudinal monitoring of tissue-engineered cartilage maturation in a preclinical implantation model.Journal of biomedical optics · 2023Article
- Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study on technical feasibility.Osteoarthritis and cartilage open · 2022Article
- Nondestructive testing of native and tissue-engineered medical products: adding numbers to pictures.Trends in biotechnology · 2022Review
- A Single Axial Impact Load Causes Articular Damage That Is Not Visible with Micro-Computed Tomography: AnCartilage · 2021Article
- Serum Calprotectin as a Blood-Based Biomarker for Monitoring Knee Osteoarthritis at Early but Not Late Stages.Cartilage · 2021Article
- A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021Article
- Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography.Biomedical optics express · 2020Article
- Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography.BMC musculoskeletal disorders · 2019Article
- Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation.Scientific reports · 2018Article
- [Chondral and osteochondral defects : Representation by imaging methods].Der Orthopade · 2017Review
- Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration.Skeletal radiology · 2016Observational
- Biomarkers of (osteo)arthritis.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is the most common chronic disease of our joints, manifested by a dynamically increasing degeneration of hyaline articular cartilage (AC). While currently no therapy can reverse this process, the few available treatment options are hampered by the inability of early diagnosis. Loss of cartilage surface, or extracellular matrix (ECM), integrity is considered the earliest sign of OA. Despite the increasing number of imaging modalities surprisingly few imaging biomarkers exist. In this narrative review, recent developments in optical coherence tomography are critically evaluated for their potential to assess different aspects of AC quality as biomarkers of OA. Special attention is paid to imaging surface irregularities, ECM organization and the evaluation of posttraumatic injuries by light-based modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.