Evidence map›Paper›PMID 26862866›Full record

ArticleJournal of medicinal chemistry2016

Lanthanides: Applications in Cancer Diagnosis and Therapy.

Ruijie D Teo, John Termini, Harry B Gray

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Review
  2. Review
  3. DNA-interacting lanthanide complexes with a DOTA-derived dipyrido[3,2-Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Characterization of LaBioengineering (Basel, Switzerland) · 2025
    Article
  9. Multifunctional metal complex systems emerging from analytical chemistry for theranostic applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ruijie D TeoDivision of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
John TerminiDepartment of Molecular Medicine, Beckman Research Institute of the City of Hope , 1500 E. Duarte Road, Duarte, California 91010, United States.
Harry B GrayDivision of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

Funding

ELECTRON-TRANSFER PROCESSES IN IRON AND COPPER PROTEINSR01DK019038 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRAY, HARRY B, WINKLER, JAY R · 1986 to 2023
$7.0M
Hyperglycemia-induced DNA damage as a driver of genomic instabilityR01CA176611 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI O'CONNOR, TIMOTHY R, TERMINI, JOHN S · 2013 to 2017
$2.1M
NCI NIH HHS R01 CA176611NIDDK NIH HHS R01 DK019038
6 · The paper itself

Abstract

Lanthanide complexes are of increasing importance in cancer diagnosis and therapy, owing to the versatile chemical and magnetic properties of the lanthanide-ion 4f electronic configuration. Following the first implementation of gadolinium(III)-based contrast agents in magnetic resonance imaging in the 1980s, lanthanide-based small molecules and nanomaterials have been investigated as cytotoxic agents and inhibitors, in photodynamic therapy, radiation therapy, drug/gene delivery, biosensing, and bioimaging. As the potential utility of lanthanides in these areas continues to increase, this timely review of current applications will be useful to medicinal chemists and other investigators interested in the latest developments and trends in this emerging field.

Indexed as

AnimalsBiosensing TechniquesContrast MediaCoordination ComplexesDrug Delivery SystemsGene Transfer TechniquesHumansLanthanoid Series ElementsMagnetic Resonance ImagingMass SpectrometryNeoplasmsOptical ImagingPhotochemotherapyRadiotherapyContrast MediaCoordination ComplexesLanthanoid Series Elements

Identifiers

PMID26862866
PMCPMC4945403

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.