ArticlePloS one2016
Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Contributions of Zebrafish Studies to the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review.Current neuropharmacology · 2022Pooled it
- Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish (Frontiers in systems neuroscience · 2026Article
- rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood.Translational psychiatry · 2025Article
- Article
- Biomechanical induction of mild brain trauma in larval zebrafish: effects on visual startle reflex habituation.Brain communications · 2023Article
- Teleosts as behaviour test models for social stress.Frontiers in behavioral neuroscience · 2023Review
- Age-related alterations in the behavioral response to a novel environment in the African turquoise killifish (Frontiers in behavioral neuroscience · 2023Article
- Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring.Biomolecules · 2022Article
- Comparison of anxiety-like and social behaviour in medaka and zebrafish.Scientific reports · 2022Article
- Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents.Current neuropharmacology · 2022Review
- Environmental enrichment decreases anxiety-like behavior in zebrafish larvae.Developmental psychobiology · 2022Article
- Behavioral Effects of Buspirone in Juvenile Zebrafish of Two Different Genetic Backgrounds.Toxics · 2022Article
- Article
- Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish.International journal of molecular sciences · 2021Article
- Sexually dimorphic and asymmetric effects of embryonic ethanol exposure on hypocretin/orexin neurons as related to behavioral changes in zebrafish.Scientific reports · 2021Article
- Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment.Frontiers in toxicology · 2021Review
- Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD).Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).Scientific reports · 2020Article
- Behavioral models in psychopathology: epistemic and semantic considerations.Behavioral and brain functions : BBF · 2019Review
- Multigenerational consequences of early-life cannabinoid exposure in zebrafish.Toxicology and applied pharmacology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In zebrafish developmentally exposed to ambient ethanol (20mM-50mM) 1-9 days post fertilization (dpf), the cortisol response to stress has been shown to be significantly attenuated in larvae, juveniles and 6 month old adults. These data are somewhat at variance with similar studies in mammals, which often show heightened stress responses. To test whether these cortisol data correlate with behavioural changes in treated animals, anxiety-like behaviour of zebrafish larvae (9dpf and 10dpf) and juveniles (23dpf) was tested in locomotor assays designed to this end. In open field tests treated animals were more exploratory, spending significantly less time at the periphery of the arena. Behavioural effects of developmental exposure to ethanol were sustained in 6-month-old adults, as judged by assessment of thigmotaxis, novel tank diving and scototaxis. Like larvae and juveniles, developmentally treated adults were generally more exploratory, and spent less time at the periphery of the arena in thigmotaxis tests, less time at the bottom of the tank in the novel tank diving tests, and less time in the dark area in scototaxis tests. The conclusion that ethanol-exposed animals showed less anxiety-like behaviour was validated by comparison with the effects of diazepam treatment, which in thigmotaxis and novel tank diving tests had similar effects to ethanol pretreatment. There is thus a possible link between the hypophyseal-pituitary-interrenal axis and the behavioural actions of developmental ethanol exposure. The mechanisms require further elucidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.