Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.

Ravirajsinh N Jadeja, Nathalie H Urrunaga, Daniel Ahmad, Sandeep Khurana

Open access · goldAbstract read

In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ravirajsinh N JadejaDivision of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, GA 30912, USA.

Nathalie H UrrunagaDivision of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Daniel AhmadDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Sandeep KhuranaDivision of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, GA 30912, USA.

Augusta University · USUniversity of Maryland, Baltimore · US

Funding

Mechanisms of Vascular Dysfunction in CirrhosisK08DK081479 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI KHURANA, SANDEEP · 2008 to 2012

$716k

NIDDK NIH HHS K08 DK081479

6 · The paper itself

Abstract

We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.

Indexed as

CatalaseMuscarinic receptorsOxidative stress

Identifiers

PMID26862589

DOI10.1016/j.dib.2015.12.025

PMCPMC4707288

OpenAlexW2215140530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.