ReviewWorld journal of clinical pediatrics2016
Short and long term prognosis in perinatal asphyxia: An update.
Review in World journal of clinical pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 122 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Investigation of Neurofilament Light Chain (NfL) Levels in Newborns Diagnosed With Hypoxic Ischemic Encephalopathy: A Case-Control Study
Who cites it
122 citing papers in PubMed, 6 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Prevalence and risk factors associated with birth asphyxia among neonates delivered in China: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Pooled it
- Prevalence and risk factors associated with birth asphyxia among neonates delivered in Ethiopia: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- Pooled it
- The effects of nutrition on mesenteric oxygenation among neonates with neonatal encephalopathy: a randomized clinical trial.Pediatric research · 2025Trial
- Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial.Italian journal of pediatrics · 2023Trial
- First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.Current clinical pharmacology · 2020Trial
- Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome.PloS one · 2017Trial
- Risk factors and mortality in infants who received bag and mask ventilation at birth: a secondary analysis from the global network maternal newborn health registry.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Influence of skin to skin contact on cardiac indices and cerebral perfusion-oxygenation in severely asphyxiated infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2026Article
- Predicting Intrapartum Acidemia: A Review of Approaches Based on Fetal Heart Rate.Bioengineering (Basel, Switzerland) · 2026Review
- Mild Neonatal Hypoxia Modifies the Reactivity of the Glucocorticoid System in Adult Rats, Promoting Improved Learning and Spatial Memory Under Stressful Conditions.Neurochemical research · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Developmental profiles of infants with hypoxic ischaemic encephalopathy at a tertiary hospital in South Africa.African journal of disability · 2026Article
- Urinary metabolome at birth in patients with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and long-term neurodevelopmental outcomes: a 7-year follow up.Journal of translational medicine · 2025Article
- Child and youth chronic physical health conditions: a comparison of survey data and linked administrative health data in Ontario.BMC pediatrics · 2025Article
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy (NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy (HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and long-term outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.