Evidence map›Paper›PMID 26862201›Full record

ReviewBiochemical Society transactions2016

Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism.

Vasilios M E Andriotis, Martin Rejzek, Michael D Rugen, Birte Svensson, Alison M Smith, Robert A Field

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemical Society transactions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vasilios M E AndriotisDepartments of Biological Chemistry and Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K. vasilios.andriotis@jic.ac.uk.
Martin RejzekDepartments of Biological Chemistry and Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Michael D RugenDepartments of Biological Chemistry and Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Birte SvenssonEnzyme and Protein Chemistry, Department of Systems Biology, Technical University of Denmark, Elektrovej, Bldg. 375, DK-2800 Kgs Lyngby, Denmark.
Alison M SmithDepartments of Biological Chemistry and Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Robert A FieldDepartments of Biological Chemistry and Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Technical University of Denmark · DK

Funding

Biotechnology and Biological Sciences Research Council BB/I017291/1Biotechnology and Biological Sciences Research Council BB/J004561/1Biotechnology and Biological Sciences Research Council BBS/E/J/000C0618
6 · The paper itself

Abstract

Starch is a major energy store in plants. It provides most of the calories in the human diet and, as a bulk commodity, it is used across broad industry sectors. Starch synthesis and degradation are not fully understood, owing to challenging biochemistry at the liquid/solid interface and relatively limited knowledge about the nature and control of starch degradation in plants. Increased societal and commercial demand for enhanced yield and quality in starch crops requires a better understanding of starch metabolism as a whole. Here we review recent advances in understanding the roles of carbohydrate-active enzymes in starch degradation in cereal grains through complementary chemical and molecular genetics. These approaches have allowed us to start dissecting aspects of starch degradation and the interplay with cell-wall polysaccharide hydrolysis during germination. With a view to improving and diversifying the properties and uses of cereal grains, it is possible that starch degradation may be amenable to manipulation through genetic or chemical intervention at the level of cell wall metabolism, rather than simply in the starch degradation pathway per se.

Indexed as

Carbohydrate MetabolismEdible GrainEndospermEnzyme InhibitorsGerminationImino SugarsPlant RootsEnzyme InhibitorsImino Sugarsarabinoxylancell wallcereal grainchemical geneticsiminosugarstarch

Identifiers

PMID26862201
PMCPMC4747157
OpenAlexW2279106657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.