ReviewThe Biochemical journal2016
New photosensitizers for photodynamic therapy.
Review in The Biochemical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03380403 (A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients), which is not on this map. Cited by 637 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
Who cites it
637 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,938 citations in OpenAlex.
- Umbrella review of photodynamic therapy for cancer: efficacy, safety, and clinical applications.Frontiers in oncology · 2025Pooled it
- LC-MS/MS-Based Phytochemical Characterization of Cakile maritima Methanol Extract and Its Photodynamic Anticancer Activity in Gastric Cancer Cells.Rapid communications in mass spectrometry : RCM · 2026Article
- Evaluating the Antimicrobial Activity of Curcumin-loaded Lipid Nanocarriers When Applying Photodynamic and Sonodynamic Therapy for the Treatment of Skin Infections.Pharmaceutical research · 2026Article
- Antimicrobial Photodynamic Therapy Associated With Systemic Treatment in Osteoradionecrosis: An In Vivo Study.Lasers in surgery and medicine · 2026Article
- Antimicrobial Strategies in the Era of Resistance: It Is Too Early to Give Up Antibiotic Therapy.International journal of molecular sciences · 2026Review
- Reprogramming Photodynamic Therapy with BODIPY Photosensitizers: From Local Phototoxicity Toward Precision Photodynamic Oncology.Molecules (Basel, Switzerland) · 2026Review
- Highly Efficient Photodynamic Inactivation of Multidrug-resistant Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter baumannii Strains by Toluidine Blue-graphene Oxide Quantum Dot/Ag Nanoparticle Conjugate.Current microbiology · 2026Article
- Recent Advances in Zinc(II)-Complexes for Antibacterial Photodynamic Therapy.Chemistry, an Asian journal · 2026Review
- The Influence of the Central Metal (Zn) in the Porphyrin Skeleton on the Mechanism Induced by Photodynamic Therapy.Cancers · 2026Review
- Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds.Chemistry & biodiversity · 2026Review
- Artificial Intelligence and Natural Photosensitizer-Based Nanopharmaceuticals in Photodynamic Therapy: Advanced Modeling, Data-Driven Optimization, and Translational Perspectives.Pharmaceutics · 2026Review
- Effects of interstitial photodynamic therapy on transplanted tumors of human lung adenocarcinoma A549 cells in nude mice.Lasers in medical science · 2026Article
- Redox-modulation of regulated cell death: implications for synergistic anticancer therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Liquid Metal Materials for Tumor Diagnosis and Treatment.Advanced healthcare materials · 2026Review
- Disinfection of poultry processing wastewater using advanced oxidation processes.Poultry science · 2026Article
- Linker dependence ofOrganic & biomolecular chemistry · 2026Article
- A versatile method for accurately predicting electronic absorption spectra of tetrapyrrole macrocycles.Scientific reports · 2026Article
- Identification and characterization of phyllochlorin sodium as a novel chlorin-derived photosensitiser.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Antimicrobial photodynamic therapy using tetra-cationic porphyrins with peripheral platinum(II) and palladium(II) complexes against multidrug-resistant bacteria isolated from canine otitis.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- 1,3,2-Dioxaborine-based mero-polyanionic dyes: high-extinction NIR-absorbing polymethines.RSC advances · 2026Article
577 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.