Evidence map›Paper›PMID 26862030›Full record

SynthesisDevelopmental medicine and child neurology2016

Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review.

Louise Linsell, Reem Malouf, Joan Morris, Jennifer J Kurinczuk, Neil Marlow

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Developmental medicine and child neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02159534 (Multicentric Prospective Randomised Single-blind Controlled Clinical Study Assessing the Effect and the Safety of Primebrain Sensorimotor Stimulation on Neurological Development of Preterm Infants), which is not on this map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02159534 naunknown statusnot on this map

Multicentric Prospective Randomised Single-blind Controlled Clinical Study Assessing the Effect and the Safety of Primebrain Sensorimotor Stimulation on Neurological Development of Preterm Infants (Born Before 32 Weeks' Gestation) or Infants Born Weighing Less Than 1500 g

TypeinterventionalSponsorQueen Fabiola Children's University HospitalRan2014 to 2020Enrolled70ConditionsPreterm InfantsArmsPrimebrain
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Administration time of caffeine in preterm infants: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025
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  5. Postnatal corticosteroids for transient tachypnoea of the newborn.The Cochrane database of systematic reviews · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Louise LinsellNational Perinatal Epidemiology Unit (NPEU), Nuffield Department of Population Health, University of Oxford, Headington, Oxford, UK.
Reem MaloufNational Perinatal Epidemiology Unit (NPEU), Nuffield Department of Population Health, University of Oxford, Headington, Oxford, UK.
Joan MorrisQueen Mary University of London, Centre for Environmental and Preventive Medicine, Barts and The London School of Medicine and Dentistry, London, UK.
Jennifer J KurinczukNational Perinatal Epidemiology Unit (NPEU), Nuffield Department of Population Health, University of Oxford, Headington, Oxford, UK.
Neil MarlowInstitute of Women's Health, University College London, London, UK.
University of Oxford · GBLondon Women's Clinic · GBQueen Mary University of London · GB

Funding

Department of Health DRF-2012-05-206Medical Research Council G0401525
6 · The paper itself

Abstract

aimThere is a large literature reporting risk factor analyses for poor neurodevelopment in children born very preterm (VPT: ≤32wks) or very low birthweight (VLBW: ≤1250g), which to date has not been formally summarized. The aim of this paper was to identify prognostic factors for cerebral palsy (CP) and motor impairment in children born VPT/VLBW.

methodA systematic review was conducted using Medline, Embase, and Pyscinfo databases to identify studies published between 1 January 1990 and 1 June 2014 reporting multivariable prediction models for poor neurodevelopment in VPT/VLBW children (registration number CRD42014006943). Twenty-eight studies for motor outcomes were identified.

resultsThere was strong evidence that intraventricular haemorrhage and periventricular leukomalacia, and some evidence that the use of postnatal steroids and non-use of antenatal steroids, were prognostic factors for CP. Male sex and gestational age were of limited use as prognostic factors for CP in cohorts restricted to ≤32 weeks gestation; however, in children older than 5 years with no major disability, there was evidence that male sex was a predictive factor for motor impairment.

interpretationThis review has identified factors which may be of prognostic value for CP and motor impairment in VPT/VLBW children and will help to form the basis of future prognostic research.

Indexed as

Infant, Very Low Birth WeightCerebral PalsyChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfant, Premature, DiseasesMaleMovement Disorders

Identifiers

PMID26862030
PMCPMC5321605
OpenAlexW2273540556

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.