Evidence map›Paper›PMID 26862008›Full record

Trial reportEuropean journal of clinical nutrition2016

Effect of meal frequency on glucose and insulin levels in women with polycystic ovary syndrome: a randomised trial.

E Papakonstantinou, I Kechribari, P Mitrou, E Trakakis, D Vassiliadi, E Georgousopoulou, A Zampelas, M D Kontogianni, G Dimitriadis

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 6 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Lifestyle changes in women with polycystic ovary syndrome.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Pooled it
  7. Article
  8. Review
  9. Circadian clock and temporal meal pattern.Medical review (2021) · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

E PapakonstantinouDepartment of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece.
I KechribariDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
P MitrouHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and its Complications (H.N.D.C), Athens, Greece.
E Trakakis2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Haidari, Greece.
D Vassiliadi2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Haidari, Greece.
E GeorgousopoulouDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
A ZampelasDepartment of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece.
M D KontogianniDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
G Dimitriadis2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Haidari, Greece.
Harokopio University of Athens · GRUniversity General Hospital Attikon · GRAgricultural University of Athens · GRHellenic Center for Disease Control & Prevention · GRUnited Arab Emirates University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe aim of the study was to compare the effect of two-meal patterns (three vs six meals per day) on glucose and insulin levels in women with polycystic ovary syndrome (PCOS). SUBJECTS/

methodsIn a randomised, crossover, 24-week study, 40 women with PCOS, aged 27±6 years, body mass index 27±6 kg/m(2), followed a weight maintenance diet (% carbohydrates:protein:fat, 40:25:35), consumed either as a three- or a six-meal pattern, with each intervention lasting for 12 weeks. Anthropometric measurements, diet compliance and subjective hunger, satiety and desire to eat were assessed biweekly. All women underwent an oral glucose tolerance test (OGTT) with 75 g glucose for measurement of plasma glucose and insulin at the beginning and end of each intervention. HaemoglobinA1c (HbA1c), blood lipids and hepatic enzymes were measured at the beginning and end of each intervention.

resultsBody weight remained stable throughout the study. Six meals decreased significantly fasting insulin (P=0.014) and post-OGTT insulin sensitivity (Matsuda index, P=0.039) vs three meals. After incorporation of individual changes over time, with adjustment for potential confounders, the only variable that remained significant was the Matsuda index, which was then used in multivariate analysis and general linear models. Six meals improved post-OGTT insulin sensitivity independently of age and body weight vs three meals (P=0.012). No significant differences were found between six and three meals for glucose, HbA1c, blood lipids, hepatic enzymes, subjective desire to eat and satiety.

conclusionsSix meals had a more favourable effect on post-OGTT insulin sensitivity in women with PCOS compared with isocaloric three meals.

Indexed as

Feeding BehaviorAdultBlood GlucoseCross-Over StudiesFastingFemaleGlucose Tolerance TestHumansInsulinInsulin ResistanceMealsPolycystic Ovary SyndromeTime FactorsYoung AdultBlood GlucoseInsulin

Identifiers

PMID26862008
OpenAlexW2263637249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.