ArticleLasers in medical science2016
Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia.
Article in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05739214 (The Effect of Combined Red and Infrared Lasers on Histopathology Collagen Formation in Diabetic Foot Ulcer), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Combined Red and Infrared Lasers on Histopathology Collagen Formation in Diabetic Foot Ulcer: a Randomized Controlled Trial
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Effects and parameterization of low-level laser therapy in diabetic ulcers: an umbrella review of systematic reviews and meta-umbrella.Lasers in medical science · 2025Pooled it
- The effect of low-level laser therapy on diabetic foot ulcers: A meta-analysis of randomised controlled trials.International wound journal · 2021Pooled it
- Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- The short-term effect of near infrared irradiation on arteriovenous fistula in hemodialysis patients: a pilot, prospective study.Scientific reports · 2026Trial
- Dose-response and efficacy of 904 nm photobiomodulation on diabetic foot ulcers healing: a randomized controlled trial.Lasers in medical science · 2024Trial
- Effects of photobiomodulation therapy (PBMT) over endothelial function in healthy individuals: a preliminary crossover clinical trial.Lasers in medical science · 2023Trial
- Photobiomodulation at 660 nm enhances proliferative activity while preserving viability in human endothelial cells in vitro.Cell and tissue banking · 2026Article
- Photobiomodulation in cardiovascular diseases: molecular mechanisms and pharmacological approaches to enhance the therapeutics effects of light.Lasers in medical science · 2025Review
- Dose-response and efficacy of 830-nanometer photobiomodulation in healing diabetic foot ulcers: randomized, double-blind, clinical trial protocol.Lasers in medical science · 2025Article
- An evaluation of photobiomodulation effects on human gingival fibroblast cells under hyperglycemic condition: an in vitro study.Lasers in medical science · 2023Article
- Physical therapy in diabetic foot ulcer: Research progress and clinical application.International wound journal · 2023Review
- Effect of 660/850 nm LED on the microcirculation of the foot: neurovascular biphasic reflex.Lasers in medical science · 2021Article
- Letter regarding "Photobiomodulation alters the viability of HUVEC cells".Lasers in medical science · 2021Article
- Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review.Life (Basel, Switzerland) · 2021Review
- Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia.Lasers in medical science · 2021Review
- Experimental and Clinical Applications of Red and Near-Infrared Photobiomodulation on Endothelial Dysfunction: A Review.Biomedicines · 2021Review
- Effects of Low Level Laser Therapy (LLLT) on Serum Values of Interleukin 6 (IL-6) in Patients with Periodontitis and Type 2 Diabetes Mellitus (T2DM).Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2021Article
- Photobiomodulation alters the viability of HUVECs cells.Lasers in medical science · 2021Article
- The effect of low-level laser irradiation on hyperglycemia-induced inflammation in human gingival fibroblasts.Lasers in medical science · 2019Article
- The effects of humic water on endothelial cells under hyperglycemic conditions: inflammation-associated parameters.Environmental geochemistry and health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is considered to be a very serious lifestyle disease leading to cardiovascular complications and impaired wound healing observed in the diabetic foot syndrome. Chronic hyperglycemia is the source of the endothelial activation. The inflammatory process in diabetes is associated with the secretion of inflammatory cytokines by endothelial cells, e.g., tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). The method of phototherapy using laser beam of low power (LLLT-low-level laser therapy) effectively supports the conventional treatment of diabetic vascular complications such as diabetic foot syndrome. The aim of our study was to evaluate the effect of low-power laser irradiation at two wavelengths (635 and 830 nm) on the secretion of inflammatory factors (TNF-α and IL-6) by the endothelial cell culture-HUVEC line (human umbilical vein endothelial cell)-under conditions of hyperglycemia. It is considered that adverse effects of hyperglycemia on vascular endothelial cells may be corrected by the action of LLLT, especially with the wavelength of 830 nm. It leads to the reduction of TNF-α concentration in the supernatant and enhancement of cell proliferation. Endothelial cells play an important role in the pathogenesis of diabetes; however, a small number of studies evaluate an impact of LLLT on these cells under conditions of hyperglycemia. Further work on this subject is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.