ArticleDiabetes care2016
Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.
Article in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults.Journal of the American Heart Association · 2024Pooled it
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Iron metabolism and type 2 diabetes mellitus: A meta-analysis and systematic review.Journal of diabetes investigation · 2020Pooled it
- Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study.Drug design, development and therapy · 2019Trial
- Ferritin and Soluble Transferrin Receptor Beyond Inflammation: Independent Associations with Fasting Glucose and Metabolic Syndrome in a Central Asian Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Body Iron Stores and Metabolic Syndrome in Adults Free of Cardiometabolic Disease From Southwestern Colombia.Biological trace element research · 2026Article
- Ferroptosis in diabetes mellitus and its complications: overview of clinical and preclinical research.Cell death discovery · 2025Review
- Association between weight-adjusted-waist index and serum ferritin in patients with type 2 diabetes.Asia Pacific journal of clinical nutrition · 2025Article
- The Interplay Between Iron Metabolism and Insulin Resistance: A Key Factor in Optimizing Obesity Management in Children and Adolescents.Nutrients · 2025Review
- Association Between Dietary Inflammatory Index and Triglyceride Glucose-Body Mass Index with Iron Deficiency in Reproductive Age Women: Evidence from NHANES 2005-2018.International journal of women's health · 2025Article
- Iron Overload Induces Hepatic Ferroptosis and Insulin Resistance by Inhibiting the Jak2/stat3/slc7a11 Signaling Pathway.Cell biochemistry and biophysics · 2024Article
- Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study.Journal of the Endocrine Society · 2024Article
- Relationship between serum iron level and physical function in heart failure patients is lost by presence of diabetes.ESC heart failure · 2024Article
- Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Iron, glucose and fat metabolism and obesity: an intertwined relationship.International journal of obesity (2005) · 2023Review
- Consensus Statement on the definition and classification of metabolic hyperferritinaemia.Nature reviews. Endocrinology · 2023Review
- A reference interval study of ferritin and transferrin levels in donors from two blood centers.Experimental and therapeutic medicine · 2023Article
- Article
- Association between systemic iron status and β-cell function and insulin sensitivity in patients with newly diagnosed type 2 diabetes.Frontiers in endocrinology · 2023Article
- Association of Serum Antioxidant Minerals and Type 2 Diabetes Mellitus in Chinese Urban Residents.Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
46 authors at 20 institutions in 9 countries.
Funding
Abstract
objectiveObservational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D. RESEARCH DESIGN AND
methodsThe European Prospective Investigation into Cancer and Nutrition-InterAct study includes 12,403 incident T2D cases and a representative subcohort of 16,154 individuals from a European cohort with 3.99 million person-years of follow-up. We studied the prospective association of ferritin, TSAT, serum iron, and transferrin with incident T2D in 11,052 cases and a random subcohort of 15,182 individuals and assessed whether these associations differed by subgroups of the population.
resultsHigher levels of ferritin and transferrin were associated with a higher risk of T2D (hazard ratio [HR] [95% CI] in men and women, respectively: 1.07 [1.01-1.12] and 1.12 [1.05-1.19] per 100 μg/L higher ferritin level; 1.11 [1.00-1.24] and 1.22 [1.12-1.33] per 0.5 g/L higher transferrin level) after adjustment for age, center, BMI, physical activity, smoking status, education, hs-CRP, alanine aminotransferase, and γ-glutamyl transferase. Elevated TSAT (≥45% vs. <45%) was associated with a lower risk of T2D in women (0.68 [0.54-0.86]) but was not statistically significantly associated in men (0.90 [0.75-1.08]). Serum iron was not associated with T2D. The association of ferritin with T2D was stronger among leaner individuals (Pinteraction < 0.01).
conclusionsThe pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D.
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