Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2016
Effectiveness of braces designed using computer-aided design and manufacturing (CAD/CAM) and finite element simulation compared to CAD/CAM only for the conservative treatment of adolescent idiopathic scoliosis: a prospective randomized controlled trial.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02285621 (Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis
Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Sagittal spinal alignment in adolescent idiopathic scoliosis: a narrative review of pre- and post-treatment characteristics.EFORT open reviews · 2026Review
- A novel spinal orthosis with embedded shape memory alloy for adolescent idiopathic scoliosis.Biomedical engineering online · 2026Article
- Brace Dose in Scoliosis: Measurement, Monitoring, and Clinical Decision-Making-A Narrative Review.Orthopedic research and reviews · 2026Review
- Research trends of biomechanics in scoliosis from 1999 to 2023: a bibliometric analysis.Spine deformity · 2025Review
- Systematic Review of Clinical Outcome Parameters of Conservative Treatment of Adolescent Idiopathic Scoliosis Patients.Journal of clinical medicine · 2025Review
- Reducing the Brace Correction Stress on the Secondary Lumbar Curve Results in Excellent Muscle, Bone, and Disc Mechanical Performance: A Musculoskeletal Finite Element Simulation of AIS Patient With Rigo A3.Orthopaedic surgery · 2025Article
- Automated design of nighttime braces for adolescent idiopathic scoliosis with global shape optimization using a patient-specific finite element model.Scientific reports · 2024Article
- 3D Printing for Personalized Solutions in Cervical Spondylosis.Orthopedic research and reviews · 2024Review
- Optimized braces for the treatment of adolescent idiopathic scoliosis: A study protocol of a prospective randomised controlled trial.PloS one · 2024Article
- Can Computer-Aided Design and Computer-Aided Manufacturing Integrating with/without Biomechanical Simulation Improve the Effectiveness of Spinal Braces on Adolescent Idiopathic Scoliosis?Children (Basel, Switzerland) · 2023Review
- Finite element analysis in brace treatment on adolescent idiopathic scoliosis.Medical & biological engineering & computing · 2022Review
- Design of personalized scoliosis braces based on differentiable biomechanics-Synthetic study.Frontiers in bioengineering and biotechnology · 2022Article
- Biomechanical Morphing for Personalized Fitting of Scoliotic Torso Skeleton Models.Frontiers in bioengineering and biotechnology · 2022Article
- Efficacy of Computer-Aided Design and Manufacturing Versus Computer-Aided Design and Finite Element Modeling Technologies in Brace Management of Idiopathic Scoliosis: A Narrative Review.Asian spine journal · 2021Article
- Spinal Deformities and Advancement in Corrective Orthoses.Bioengineering (Basel, Switzerland) · 2020Review
- 3D-printed brace in the treatment of adolescent idiopathic scoliosis: a study protocol of a prospective randomised controlled trial.BMJ open · 2020Article
- Evaluation of the efficiency of Boston brace on scoliotic curve control: A review of literature.The journal of spinal cord medicine · 2020Review
- The construction of the scoliosis 3D finite element model and the biomechanical analysis of PVCR orthopaedy.Saudi journal of biological sciences · 2020Article
- Determination of Three-Dimensional Corrective Force in Adolescent Idiopathic Scoliosis and Biomechanical Finite Element Analysis.Frontiers in bioengineering and biotechnology · 2020Article
- Bracing In The Treatment Of Adolescent Idiopathic Scoliosis: Evidence To Date.Adolescent health, medicine and therapeutics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClinical assessment of immediate in-brace effect of braces designed using CAD/CAM and FEM vs. only CAD/CAM for conservative treatment of AIS, using a randomized blinded and controlled study design.
methodsForty AIS patients were prospectively recruited and randomized into two groups. For 19 patients (control group), the brace was designed using a scan of patient's torso and a conventional CAD/CAM approach (CtrlBrace). For the 21 other patients (test group), the brace was additionally designed using finite element modeling (FEM) and 3D reconstructions of spine, rib cage and pelvis (NewBrace). The NewBrace design was simulated and iteratively optimized to maximize the correction and minimize the contact surface and material.
resultsBoth groups had comparable age, sex, weight, height, curve type and severity. Scoliosis Research Society standardized criteria for bracing were followed. Average Cobb angle prior to bracing was 27° and 28° for main thoracic (MT) and lumbar (L) curves, respectively, for the control group, while it was 33° and 28° for the test group. CtrlBraces reduced MT and L curves by 8° (29 %) and 10° (40 %), respectively, compared to 14° (43 %) and 13° (46 %) for NewBraces, which were simulated with a difference inferior to 5°. NewBraces were 50 % thinner and had 20 % less covering surface than CtrlBraces.
conclusionBraces designed with CAD/CAM and 3D FEM simulation were more efficient and lighter than standard CAD/CAM TLSO's at first immediate in-brace evaluation. These results suggest that long-term effect of bracing in AIS may be improved using this new platform for brace fabrication.
trial registrationNCT02285621.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.