ArticleScientific reports2016
The agar diffusion scratch assay--A novel method to assess the bioactive and cytotoxic potential of new materials and compounds.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Analysis of the Antioxidant and Antimicrobial Activity, Cytotoxic, and Anti-Migratory Properties of the Essential Oils Obtained from Cultivated MedicinalPlants (Basel, Switzerland) · 2025Article
- Article
- Assessing Leachable Cytotoxicity of 3D-Printed Polymers and Facile Detoxification Methods.3D printing and additive manufacturing · 2023Article
- Isolation and Molecular Characterization of Two Novel Lytic Bacteriophages for the Biocontrol ofPharmaceutics · 2022Article
- Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy.Pharmaceutics · 2022Article
- Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Multifunctional Ginger Nanofiber Hydrogels with Tunable Absorption: The Potential for Advanced Wound Dressing Applications.Biomacromolecules · 2021Article
- Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A profound in vitro evaluation not only of the cytotoxic but also of bioactive potential of a given compound or material is crucial for predicting potential effects in the in vivo situation. However, most of the current methods have weaknesses in either the quantitative or qualitative assessment of cytotoxicity and/or bioactivity of the test compound. Here we describe a novel assay combining the ISO 10993-5 agar diffusion test and the scratch also termed wound healing assay. In contrast to these original tests this assay is able to detect and distinguish between cytotoxic, cell migration modifying and cytotoxic plus cell migration modifying compounds, and this at higher sensitivity and in a quantitative way.
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