ArticleInternational journal of epidemiology2016
Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice.Rheumatology (Oxford, England) · 2023Guideline
- Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure.Biomedicines · 2025Article
- A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025Article
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity.Pediatrics · 2024Article
- Early-life risk factors which govern pro-allergic immunity.Seminars in immunopathology · 2024Review
- Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice.Rheumatology (Oxford, England) · 2023Article
- Effects of Prenatal Paracetamol Exposure on the Development of Asthma and Wheezing in Childhood: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Prenatal opioid exposure and risk of asthma in childhood: a population-based study from Denmark, Norway, and Sweden.Frontiers in pharmacology · 2023Article
- Paracetamol preceding very preterm birth: Is it safe?Acta obstetricia et gynecologica Scandinavica · 2022Article
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Environmental exposure during pregnancy and the risk of childhood allergic diseases.World journal of pediatrics : WJP · 2021Review
- Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California.International journal of environmental research and public health · 2021Article
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- Behavioral Problems at Age 11 Years After Prenatal and Postnatal Exposure to Acetaminophen: Parent-Reported and Self-Reported Outcomes.American journal of epidemiology · 2021Article
- Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.Current environmental health reports · 2021Review
- Article
- Prevention of Asthma: Targets for Intervention.Chest · 2020Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundParacetamol exposure has been positively associated with asthma development. The relative importance of prenatal vs infant exposure and confounding by indication remains elusive. We examined the association of prenatal and infant (first 6 months) paracetamol exposure with asthma development while addressing confounding by indication.
methodsWe used information from the Norwegian Mother and Child Cohort Study, including 53169 children for evaluation of current asthma at 3 years, 25394 for current asthma at 7 years and 45607 for dispensed asthma medications at 7 years in the Norwegian Prescription Database. We calculated adjusted relative risks (adj. RR) and 95% confidence intervals (CI) using log-binomial regression.
resultsThere were independent modest associations between asthma at 3 years with prenatal paracetamol exposure (adj. RR 1.13; 95% CI: 1.02-1.25) and use of paracetamol during infancy (adj. RR 1.29; 95% CI: 1.16-1.45). The results were consistent for asthma at 7 years. The associations with prenatal paracetamol exposure were seen for different indications (pain, respiratory tract infections/influenza and fever). Maternal pain during pregnancy was the only indication that showed an association both with and without paracetamol use. Maternal paracetamol use outside pregnancy and paternal paracetamol use were not associated with asthma development. In a secondary analysis, prenatal ibuprofen exposure was positively associated with asthma at 3 years but not asthma at 7 years.
conclusionsThis study provides evidence that prenatal and infant paracetamol exposure have independent associations with asthma development. Our findings suggest that the associations could not be fully explained by confounding by indication.
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