Evidence map›Paper›PMID 26861414›Full record

SynthesisNature communications2016

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns.

Bonnie R Joubert, Herman T den Dekker, Janine F Felix, Jon Bohlin, Symen Ligthart, Emma Beckett, Henning Tiemeier, Joyce B van Meurs, Andre G Uitterlinden, Albert Hofman and 19 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 16 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 16 syntheses or guidelines pooled it, 264 citations in OpenAlex.

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  13. Epigenome-wide meta-analysis of DNA methylation and childhood asthma.The Journal of allergy and clinical immunology · 2019
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 8 institutions in 4 countries.

Bonnie R JoubertDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.ORCID http://orcid.org/0000-0001-7952-1180
Herman T den DekkerThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Jon BohlinNorwegian Institute of Public Health, Oslo 0403, Norway.
Symen LigthartDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Emma BeckettDepartment of Applied Sciences, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, New South Wales 2258, Australia.
Henning TiemeierDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.ORCID http://orcid.org/0000-0002-4395-1397
Joyce B van MeursDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Andre G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Siri E HåbergNorwegian Institute of Public Health, Oslo 0403, Norway.
Sarah E ReeseDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Marjolein J PetersDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Bettina Kulle AndreassenDepartment of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo 0316, Norway.
Eric A P SteegersDepartment of Obstetrics and Gynaecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Roy M NilsenDepartment of Research and Development, Centre for Clinical Research, Haukeland University Hospital, Bergen 5021, Norway.
Stein E VollsetNorwegian Institute of Public Health, Oslo 0403, Norway.
Øivind MidttunBevital A/S, Laboratoriebygget, Bergen 5018, Norway.
Per M UelandDepartment of Clinical Science, University of Bergen, Bergen 5018, Norway.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Johan C de JongsteDepartment of Pediatrics, Division of Respiratory Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Michael C WuPublic Health Sciences Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Tianyuan WangDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Shyamal D PeddadaDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Wenche NystadNorwegian Institute of Public Health, Oslo 0403, Norway.
Liesbeth DuijtsThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, Netherlands.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.ORCID http://orcid.org/0000-0003-4911-5290
Erasmus MC · NLNational Institutes of Health · USNorwegian Institute of Public Health · NOHaukeland University Hospital · NOBevital (Norway) · NOCommonwealth Scientific and Industrial Research Organisation · AUFred Hutch Cancer Center · USUniversity of Oslo · NO

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Collaborative research in environmental health sciencesZIAES103066 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PEDDADA, SHYAMAL · 2012 to 2017
$732k
GENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537k
Intramural NIH HHS Z01 ES049019NIEHS NIH HHS N01 ES075558NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina's HumanMethyl450 Beadchip in 1,988 newborns from two European cohorts. Here we report the combined covariate-adjusted results using meta-analysis and employ pathway and gene expression analyses. Four-hundred forty-three CpGs (320 genes) are significantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%); 48 are significant after Bonferroni correction. Most genes are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21. Some relate to birth defects other than neural tube defects, neurological functions or varied aspects of embryonic development. These findings may inform how maternal folate impacts the developing epigenome and health outcomes in offspring.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression Regulation, DevelopmentalAdultCell Adhesion MoleculesCytoskeletal ProteinsFemaleFolic AcidGPI-Linked ProteinsHumansInfant, NewbornKallikreinsLIM-Homeodomain ProteinsMonocarboxylic Acid TransportersPeripherinsPregnancyAPC2 protein, humanCell Adhesion MoleculesCytoskeletal ProteinsFolic AcidGPI-Linked Proteinskallikrein 4KallikreinsLHX1 protein, humanLIM-Homeodomain ProteinsMonocarboxylic Acid TransportersOPCML protein, humanPeripherinsPRPH protein, humanPRSS21 protein, humanSerine EndopeptidasesSLC16A12 protein, humanTranscription Factors

Identifiers

PMID26861414
PMCPMC4749955
OpenAlexW2468762222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.