ReviewBiology2016
Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine.
Review in Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- The multidimensional effects of sleep quality in young adults: the relationship between auditory performance, sound tolerance, and anxiety.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Sleep and infant development in the first year.Pediatric research · 2026Article
- Hypersomnolence in focus: a white paper of the 6th Think Tank World Sleep Forum.Sleep medicine · 2025Review
- Sleep in Disorders of Consciousness: A Brief Overview on a Still under Investigated Issue.Brain sciences · 2023Review
- The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine AInternational journal of molecular sciences · 2020Review
- Neural correlates of dynamic changes in working memory performance during one night of sleep deprivation.Human brain mapping · 2019Article
- Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.Journal of circadian rhythms · 2019Article
- A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner.Journal of sleep research · 2019Article
- Association betweenNeuropsychiatric disease and treatment · 2019Article
- Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.Neurochemical research · 2019Review
- Neuroendocrine Control of Sleep.Current topics in behavioral neurosciences · 2019Review
- Intracerebral Adenosine During Sleep Deprivation: A Meta-Analysis and New Experimental Data.Journal of circadian rhythms · 2018Article
- Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement.Scientific reports · 2018Article
- Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder.Frontiers in physiology · 2018Review
- Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal.Frontiers in neurology · 2018Review
- Changes of Cerebral and/or Peripheral Adenosine A₁ Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats.International journal of molecular sciences · 2017Article
- Exploring the nap paradox: are mid-day sleep bouts a friend or foe?Sleep medicine · 2017Review
- Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration.Molecules (Basel, Switzerland) · 2017Review
- The role of sleep in bipolar disorder.Nature and science of sleep · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sleep-wake cycle is regulated by a fine-tuned interplay between sleep-homeostatic and circadian mechanisms. Compelling evidence suggests that adenosine plays an important role in mediating the increase of homeostatic sleep pressure during time spent awake and its decrease during sleep. Here, we summarize evidence that adenosinergic mechanisms regulate not only the dynamic of sleep pressure, but are also implicated in the interaction of homeostatic and circadian processes. We review how this interaction becomes evident at several levels, including electrophysiological data, neuroimaging studies and behavioral observations. Regarding complex human behavior, we particularly focus on sleep-wake regulatory influences on working memory performance and underlying brain activity, with a specific emphasis on the role of adenosine in this interplay. We conclude that a change in adenosinergic mechanisms, whether exogenous or endogenous, does not only impact on sleep-homeostatic processes, but also interferes with the circadian timing system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.