ArticleToxins2016
Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin α, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development.
Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- ZnO-CuO nanocomposites for sustainable water treatment linking photocatalytic efficiency with ecotoxicological safety.Scientific reports · 2026Article
- Microbial Detoxification of Ochratoxin A in Food.Foods (Basel, Switzerland) · 2026Review
- Detoxification of Ochratoxin a byToxins · 2026Article
- Article
- Occurrence of mycotoxins in fish feed and its consequences for aquaculture with special regard to the role of insect products.Mycotoxin research · 2026Review
- Microbial and enzymatic biodegradation of aflatoxins and ochratoxins: mechanisms, applications, and emerging innovations.Archives of microbiology · 2026Review
- Isolation and Characterization ofFoods (Basel, Switzerland) · 2026Article
- Simultaneous mitigation of ochratoxin A and zearalenone by Amano lipase A: conditions and application.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Mycotoxin Biodegradation byToxins · 2024Review
- Article
- Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms.Archives of toxicology · 2024Article
- Article
- Interaction of Fumonisin B1,Biomolecules · 2023Article
- Enzymatic degradation of ochratoxin A in the gastrointestinal tract of piglets.Journal of animal science · 2023Article
- IsoenzymeMicrobiology spectrum · 2022Article
- Degradation of Ochratoxin A by a UV-MutatedToxins · 2022Article
- An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling.Scientific reports · 2022Article
- A Superefficient Ochratoxin A Hydrolase with Promising Potential for Industrial Applications.Applied and environmental microbiology · 2022Article
- Biological Detoxification of Mycotoxins: Current Status and Future Advances.International journal of molecular sciences · 2022Review
- In Vivo Toxicity Evaluation of Sugar AdulteratedMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Ochratoxins, and particularly ochratoxin A (OTA), are toxic fungal-derived contaminants of food and other agricultural products. Growing evidence supports the degradation of OTA by chemical, enzymatic and/or microbial means as a potential approach to remove this mycotoxin from food products. In particular, hydrolysis of OTA to ochratoxin α (OTα) and phenylalanine is the presumptive product of degradation in most cases. In the current study, we employed the zebrafish (Danio rerio) embryo, as a model of vertebrate development to evaluate, the teratogenicity of OTA and OTα. These studies show that OTA is potently active in the zebrafish embryo toxicity assay (ZETA), and that toxicity is both concentration- and time-dependent with discernible and quantifiable developmental toxicity observed at nanomolar concentrations. On the other hand, OTα had no significant effect on embryo development at all concentrations tested supporting a decreased toxicity of this degradation product. Taken together, these results suggest that ZETA is a useful, and highly sensitive, tool for evaluating OTA toxicity, as well as its degradation products, toward development of effective detoxification strategies. Specifically, the results obtained with ZETA, in the present study, further demonstrate the toxicity of OTA, and support its degradation via hydrolysis to OTα as an effective means of detoxification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.