Evidence map›Paper›PMID 26861389›Full record

ArticleNutrients2016

A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations.

Christopher R D'Adamo, Antonietta D'Urso, Kathleen A Ryan, Laura M Yerges-Armstrong, Richard D Semba, Nanette I Steinle, Braxton D Mitchell, Alan R Shuldiner, Patrick F McArdle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher R D'AdamoDepartment of Family & Community Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. cdadamo@som.umaryland.edu.
Antonietta D'UrsoThe Commonwealth Medical College, Scranton, PA 18509, USA. adurso@tcmc.edu.
Kathleen A RyanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. kryan@medicine.umaryland.edu.
Laura M Yerges-ArmstrongDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. lyerges@medicine.umaryland.edu.
Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. rdsemba@jhmi.edu.
Nanette I SteinleDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. nsteinle@medicine.umaryland.edu.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. bmitchel@medicine.umaryland.edu.
Alan R ShuldinerDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. ashuldin@medicine.umaryland.edu.
Patrick F McArdleDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. pmcardle@medicine.umaryland.edu.

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Summer Program in Obesity, Diabetes and Nutrition Training (SPORT)T35DK095737 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI STEINLE, NANETTE I · 2012 to 2021
$859k
NIDDK NIH HHS P30 DK072488NIDDK NIH HHS T35 DK095737
6 · The paper itself

Abstract

Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10(-9)). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations.

Indexed as

GenotypePolymorphism, Single NucleotideAdultAmishAntioxidantsCarotenoidsDietFemaleGenome-Wide Association StudyHistone-Lysine N-MethyltransferaseHumansIntronsLycopeneMaleMiddle AgedProstatic NeoplasmsAntioxidantsCarotenoidsHistone-Lysine N-MethyltransferaseLycopeneSETD7 protein, humancarotenoidsgenome-wide association study (GWAS)lycopeneOld Order Amishprostate cancerSCARB1SETD7

Identifiers

PMID26861389
PMCPMC4772045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.