Evidence map›Paper›PMID 26861305›Full record

ReviewInternational journal of molecular sciences2016

Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles.

Bin Zhang, Ronne Wee Yeh Yeo, Kok Hian Tan, Sai Kiang Lim

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04202783 (The Use of Exosomes In Craniofacial Neuralgia), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04202783 nasuspendednot on this mapstarted 2023, after this paper: background citation

The Use of Exosomes In Craniofacial Neuralgia

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2023 to 2024Enrolled100ConditionsNeuralgiaArmsExosomes
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bin ZhangExosome and Secreted Nano-vesicle Group, AA*STAR Institute of Medical Biology, 8A Biomedical Grove, #05-05 Immunos, Singapore 138648, Singapore. bin.zhang@imb.a-star.edu.sg.
Ronne Wee Yeh YeoExosome and Secreted Nano-vesicle Group, AA*STAR Institute of Medical Biology, 8A Biomedical Grove, #05-05 Immunos, Singapore 138648, Singapore. ronne.yeo@imb.a-star.edu.sg.
Kok Hian TanDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road Women's Tower, Level 3, Singapore 229899, Singapore. tan.kok.hian@kkh.com.sg.
Sai Kiang LimExosome and Secreted Nano-vesicle Group, AA*STAR Institute of Medical Biology, 8A Biomedical Grove, #05-05 Immunos, Singapore 138648, Singapore. saikiang.lim@imb.a-star.edu.sg.
Agency for Science, Technology and Research · SGKK Women's and Children's Hospital · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intense research focus on stem and progenitor cells could be attributed to their differentiation potential to generate new cells to replace diseased or lost cells in many highly intractable degenerative diseases, such as Alzheimer disease, multiple sclerosis, and heart diseases. However, experimental and clinical studies have increasingly attributed the therapeutic efficacy of these cells to their secretion. While stem and progenitor cells secreted many therapeutic molecules, none of these molecules singly or in combination could recapitulate the functional effects of stem cell transplantations. Recently, it was reported that extracellular vesicles (EVs) could recapitulate the therapeutic effects of stem cell transplantation. Based on the observations reported thus far, the prevailing hypothesis is that stem cell EVs exert their therapeutic effects by transferring biologically active molecules such as proteins, lipids, mRNA, and microRNA from the stem cells to injured or diseased cells. In this respect, stem cell EVs are similar to EVs from other cell types. They are both primarily vehicles for intercellular communication. Therefore, the differentiating factor is likely due to the composition of their cargo. The cargo of EVs from different cell types are known to include a common set of proteins and also proteins that reflect the cell source of the EVs and the physiological or pathological state of the cell source. Hence, elucidation of the stem cell EV cargo would provide an insight into the multiple physiological or biochemical changes necessary to affect the many reported stem cell-based therapeutic outcomes in a variety of experimental models and clinical trials.

Indexed as

Drug Delivery SystemsAnimalsExosomesExtracellular VesiclesHumansRegenerationStem Cellscellular regenerative therapeuticsexosomesextracellular vesiclesstem cells

Identifiers

PMID26861305
PMCPMC4783908
OpenAlexW2254557229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.