Evidence map›Paper›PMID 26861302›Full record

ReviewInternational journal of molecular sciences2016

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles.

Nunzio Iraci, Tommaso Leonardi, Florian Gessler, Beatriz Vega, Stefano Pluchino

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 1 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 1 synthesis or guideline pooled it, 295 citations in OpenAlex.

  1. Pooled it
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  7. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nunzio IraciWellcome Trust-Medical Research Council Stem Cell Institute, Clifford Allbutt Building-Cambridge Biosciences Campus, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, Hills Road CB2 0PY, UK. ni238@cam.ac.uk.
Tommaso LeonardiWellcome Trust-Medical Research Council Stem Cell Institute, Clifford Allbutt Building-Cambridge Biosciences Campus, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, Hills Road CB2 0PY, UK. tl344@cam.ac.uk.
Florian GesslerWellcome Trust-Medical Research Council Stem Cell Institute, Clifford Allbutt Building-Cambridge Biosciences Campus, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, Hills Road CB2 0PY, UK. fag21@cam.ac.uk.
Beatriz VegaWellcome Trust-Medical Research Council Stem Cell Institute, Clifford Allbutt Building-Cambridge Biosciences Campus, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, Hills Road CB2 0PY, UK. bv270@cam.ac.uk.
Stefano PluchinoWellcome Trust-Medical Research Council Stem Cell Institute, Clifford Allbutt Building-Cambridge Biosciences Campus, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, Hills Road CB2 0PY, UK. spp24@cam.ac.uk.
Wellcome/MRC Cambridge Stem Cell Institute · GBMedical Research Council · GB

Funding

European Research Council 260511Medical Research Council MC_PC_12009Wellcome Trust
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane vesicles, with distinct biogenesis routes, biophysical properties and different functions both in physiological conditions and in disease. The release of EVs is a widespread biological process, which is conserved across species. In recent years, numerous studies have demonstrated that several bioactive molecules are trafficked with(in) EVs, such as microRNAs, mRNAs, proteins and lipids. The understanding of their final impact on the biology of specific target cells remains matter of intense debate in the field. Also, EVs have attracted great interest as potential novel cell-free therapeutics. Here we describe the proposed physiological and pathological functions of EVs, with a particular focus on their molecular content. Also, we discuss the advances in the knowledge of the mechanisms regulating the secretion of EV-associated molecules and the specific pathways activated upon interaction with the target cell, highlighting the role of EVs in the context of the immune system and as mediators of the intercellular signalling in the brain.

Indexed as

Cell CommunicationSignal TransductionAnimalsBiological TransportCell Transformation, NeoplasticDisease SusceptibilityDrug Delivery SystemsExosomesExtracellular VesiclesHumansImmunomodulationProteinsRNAProteinsRNAdrug deliveryexosomesextracellular RNAsextracellular vesiclesintercellular communicationneurosciencesignalling pathwaytrafficking

Identifiers

PMID26861302
PMCPMC4783905
OpenAlexW2269341591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.