ArticleScientific reports2016
A specialist herbivore pest adaptation to xenobiotics through up-regulation of multiple Cytochrome P450s.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 134 citations in OpenAlex.
- Stage-Specific Insecticidal Activity of Thymol Against Colorado Potato Beetle and Time-Dependent Detoxification Gene Expression.Chemistry & biodiversity · 2026Article
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- Evaluation of Novel Dillapiol Analogs as Insect Detoxification Enzyme Inhibitors and Insecticide Synergists.Insects · 2026Article
- Defense Responses of Cucumber and Cowpea toPlants (Basel, Switzerland) · 2026Article
- Article
- Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026Review
- Pleiotropic Function of Antenna-Specific Odorant-Binding Protein Links Xenobiotic Adaptation and Olfaction inInsects · 2025Article
- Bulk Segregant Analysis Reveals Genomic Regions Associated With Imidacloprid Resistance in the Colorado Potato Beetle.Ecology and evolution · 2025Article
- Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors.Scientific reports · 2025Article
- Article
- Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.Insect science · 2025Article
- SilencingInsects · 2024Article
- Transcriptome Analysis Unveils Molecular Mechanisms of Acaricide Resistance in Two-Spotted Spider Mite Populations on Hops.International journal of molecular sciences · 2024Article
- Where Does All the Poison Go? Investigating Toxicokinetics of Newt (Taricha) Tetrodotoxin (TTX) in Garter Snakes (Thamnophis).Journal of chemical ecology · 2024Article
- Article
- The Role ofInsects · 2024Article
- Genome-Wide Comparative Analysis of the Cytochrome P450 Monooxygenase Family in 19 Aphid Species and Their Expression Analysis in 4 Cereal Crop Aphids.International journal of molecular sciences · 2024Article
- Girdling behavior of the longhorn beetle modulates the host plant to enhance larval performance.BMC ecology and evolution · 2024Article
- Function of Cytochrome P450s and Gut Microbiome in Biopesticide Adaptation ofInternational journal of molecular sciences · 2023Article
- Leveraging RNA Interference to Impact Insecticide Resistance in the Colorado Potato Beetle,Insects · 2023Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adaptation of herbivorous insects to their host plants is hypothesized to be intimately associated with their ubiquitous development of resistance to synthetic pesticides. However, not much is known about the mechanisms underlying the relationship between detoxification of plant toxins and synthetic pesticides. To address this knowledge gap, we used specialist pest Colorado potato beetle (CPB) and its host plant, potato, as a model system. Next-generation sequencing (454 pyrosequencing) was performed to reveal the CPB transcriptome. Differential expression patterns of cytochrome P450 complement (CYPome) were analyzed between the susceptible (S) and imidacloprid resistant (R) beetles. We also evaluated the global transcriptome repertoire of CPB CYPome in response to the challenge by potato leaf allelochemicals and imidacloprid. The results showed that more than half (51.2%) of the CBP cytochrome P450 monooxygenases (P450s) that are up-regulated in the R strain are also induced by both host plant toxins and pesticide in a tissue-specific manner. These data suggest that xenobiotic adaptation in this specialist herbivore is through up-regulation of multiple P450s that are potentially involved in detoxifying both pesticide and plant allelochemicals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.