ArticleAmerican journal of epidemiology2016
The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neglected model validation of antimicrobial resistance transmission models - a systematic review.Antimicrobial resistance and infection control · 2025Pooled it
- Reconstructing healthcare networks from patient transfer data: A systematic review.PLOS digital health · 2026Article
- Detection of New Delhi metallo-β-lactamase (blaScientific reports · 2026Article
- Carbapenem resistance and hypervirulence iniScience · 2026Review
- The contribution of community transmission to the burden of hospital-associated pathogens: A systematic scoping review of epidemiological models.One health (Amsterdam, Netherlands) · 2025Review
- How Systems Mapping Can Be an Important Health Communication Tool.Journal of health communication · 2025Article
- Carbapenemase-producing enterobacterales colonisation status does not lead to more frequent admissions: a linked patient study.Antimicrobial resistance and infection control · 2024Article
- Regional impact of multidrug-resistant organism prevention bundles implemented by facility type: A modeling study.Infection control and hospital epidemiology · 2024Article
- Molecular characteristics, fitness, and virulence of high-risk and non-high-risk clones of carbapenemase-producingMicrobiology spectrum · 2024Article
- Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting.BMC medicine · 2023Article
- Decrease in Mortality from Sepsis: Impact of the Multidisciplinary Program for the Hematologic Patient at Very High Risk.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- Cost-effectiveness of carbapenem-resistant Enterobacteriaceae (CRE) surveillance in Maryland.Infection control and hospital epidemiology · 2022Article
- Article
- Analysis of Risk Factors and Mortality of Patients with Carbapenem-ResistantInfection and drug resistance · 2022Article
- Efficacy ofJournal of microbiology and biotechnology · 2021Article
- Insights into multidrug-resistantExperimental and therapeutic medicine · 2021Article
- Modeling Interventions to Reduce the Spread of Multidrug-Resistant Organisms Between Health Care Facilities in a Region.JAMA network open · 2021Article
- Single-dose amikacin plus 7 days of amoxicillin/clavulanate to treat acute cystitis caused by extended-spectrum beta-lactamase-producingInvestigative and clinical urology · 2021Observational
- How Long-Term Acute Care Hospitals Can Play an Important Role in Controlling Carbapenem-Resistant Enterobacteriaceae in a Region: A Simulation Modeling Study.American journal of epidemiology · 2021Article
- Carbapenem-Resistant Enterobacterales in Long-Term Care Facilities: A Global and Narrative Review.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE), a group of pathogens resistant to most antibiotics and associated with high mortality, are a rising emerging public health threat. Current approaches to infection control and prevention have not been adequate to prevent spread. An important but unproven approach is to have hospitals in a region coordinate surveillance and infection control measures. Using our Regional Healthcare Ecosystem Analyst (RHEA) simulation model and detailed Orange County, California, patient-level data on adult inpatient hospital and nursing home admissions (2011-2012), we simulated the spread of CRE throughout Orange County health-care facilities under 3 scenarios: no specific control measures, facility-level infection control efforts (uncoordinated control measures), and a coordinated regional effort. Aggressive uncoordinated and coordinated approaches were highly similar, averting 2,976 and 2,789 CRE transmission events, respectively (72.2% and 77.0% of transmission events), by year 5. With moderate control measures, coordinated regional control resulted in 21.3% more averted cases (n = 408) than did uncoordinated control at year 5. Our model suggests that without increased infection control approaches, CRE would become endemic in nearly all Orange County health-care facilities within 10 years. While implementing the interventions in the Centers for Disease Control and Prevention's CRE toolkit would not completely stop the spread of CRE, it would cut its spread substantially, by half.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.