Evidence map›Paper›PMID 26861220›Full record

ArticleBiomolecular NMR assignments2016

Chemical shift assignments of the C-terminal EF-hand domain of α-actinin-1.

Matthew Turner, David E Anderson, Sahana Rajan, Johannes W Hell, James B Ames

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew TurnerDepartment of Chemistry, University of California, Davis, Davis, CA, 95616, USA.
David E AndersonDepartment of Chemistry, University of California, Davis, Davis, CA, 95616, USA.
Sahana RajanDepartment of Chemistry, University of California, Davis, Davis, CA, 95616, USA.
Johannes W HellDepartment of Pharmacology, University of California, Davis, Davis, CA, 95616, USA.
James B AmesDepartment of Chemistry, University of California, Davis, Davis, CA, 95616, USA. jbames@ucdavis.edu.
University of California, Davis · US

Funding

MEMBRANE TARGETING CALCIUM SENSORS IN VISIONR01EY012347 · NEI · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI AMES, JAMES B · 1999 to 2023
$6.9M
Subcellular Localization of Cav1.2 by alpha-actininR01AG017502 · NIA · UNIVERSITY OF WISCONSIN MADISON · PI HELL, JOHANNES W · 2000 to 2011
$3.3M
Subcellular Localization of Cav1.2 by a-actininR56AG017502 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2015 to 2015
$381k
NEI NIH HHS EY012347NEI NIH HHS R01 EY012347NIA NIH HHS AG017502NIA NIH HHS R01 AG017502NIA NIH HHS R56 AG017502
6 · The paper itself

Abstract

The regulation and localization of the neuronal voltage gated Ca(2+) channel CaV1.2 is important for synaptic plasticity associated with learning and memory. The cytoskeletal protein, α-actinin-1 is known to interact with CaV1.2 and stabilize its localization at the postsynaptic membrane. Here we report both backbone and sidechain NMR assignments for the C-terminal EF-hands (EF3 and EF4) of α-actinin-1 (residues 824-892, called ACTN_EF34) bound to the IQ-motif (residues 1644-1665) from CaV1.2 (BMRB accession no. 25902).

Indexed as

EF Hand MotifsNuclear Magnetic Resonance, BiomolecularActininAmino Acid SequenceHumansActininACTN1 protein, humanCaV1.2EF-handIQ-motifLong-term depressionSynaptic plasticityα-Actinin-1

Identifiers

PMID26861220
PMCPMC4789133
OpenAlexW2265553830

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.