ArticleCardiovascular diabetology2016
Use of imaging and clinical data to screen for cardiovascular disease in asymptomatic diabetics.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effect of sitagliptin on tissue characteristics of the carotid wall in patients with type 2 diabetes: a post hoc sub-analysis of the sitagliptin preventive study of intima-media thickness evaluation (SPIKE).Cardiovascular diabetology · 2018Trial
- Single-Cell Analysis, Spatial Transcriptomics and Molecular Docking Unveil Potential Therapeutic Targets for Carotid Atherosclerosis.Balkan medical journal · 2026Article
- Exploring unsupervised learning techniques for early detection of myocardial ischemia in type 2 diabetes.Frontiers in endocrinology · 2025Article
- Review
- Cardiac MRI for Patients with Increased Cardiometabolic Risk.Radiology. Cardiothoracic imaging · 2021Article
- High Burden of Carotid Atherosclerosis in Rural Northeast China: A Population-Based Study.Frontiers in neurology · 2021Article
- Cardiovascular Magnetic Resonance as Pathophysiologic Tool in Diabetes Mellitus.Frontiers in endocrinology · 2021Review
- Recent Updates on Vascular Complications in Patients with Type 2 Diabetes Mellitus.Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Impact of diabetes duration on heart failure in Korean patients without clinical cardiovascular disease.Medicine · 2019Observational
- Vascular Events and Carotid Atherosclerosis: A 5-Year Prospective Cohort Study in Patients with Type 2 Diabetes and a Contemporary Cardiovascular Prevention Treatment.Journal of diabetes research · 2019Article
- Association between coronary artery atherosclerosis and plasma glucose levels assessed by dual-source computed tomography.Journal of thoracic disease · 2018Article
- Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals.Cardiovascular diabetology · 2018Article
- Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes.Cardiovascular diabetology · 2017Article
- Sex difference in the risk for exercise-induced albuminuria correlates with hemoglobin A1C and abnormal exercise ECG test findings.Cardiovascular diabetology · 2017Article
- Impact of diabetes duration and degree of carotid artery stenosis on major adverse cardiovascular events: a single-center, retrospective, observational cohort study.Cardiovascular diabetology · 2017Article
- Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry.Cardiovascular diabetology · 2017Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence to suggest that not all individuals with type 2 diabetes mellitus (T2DM) have equal risk for developing cardiovascular disease. We sought to compare the yield of testing for pre-clinical atherosclerosis with various approaches.
methods98 asymptomatic individuals with T2DM without known coronary artery disease (CAD) were enrolled in a prospective study and underwent carotid ultrasound, exercise treadmill testing (ETT), coronary artery calcium (CAC) scoring, and coronary computed tomography angiography (CTA).
resultsOf 98 subjects (average age 55 ± 6, 64 % female), 43 (44 %) had coronary plaque detectable on CTA, and 38 (39 %) had CAC score >0. By CTA, 16 (16 %) had coronary stenosis ≥50 %, including three subjects with CAC = 0. Subjects with coronary plaque had greater prevalence of carotid plaque (58 % vs. 38 %, p = 0.01) and greater carotid intima media thickness (0.80 ± 0.20 mm vs. 0.70 ± 0.11 mm, p = 0.02). Notably, 18 of 55 subjects (33 %) with normal CTA had carotid plaque. Eight subjects had a positive ETT, of whom five had ≥ 50 % coronary stenosis, two had <50 % stenosis, and one had no CAD. Among these tests, CAC scoring had the highest sensitivity and specificity for prediction of CAD.
conclusionAmong asymptomatic subjects with T2DM, a majority (56 %) had no CAD by CTA. When compared to CTA, CAC was the most accurate screening modality for detection of CAD, while ETT and carotid ultrasound were less sensitive and specific. However, 33 % of subjects with normal coronary CTA had carotid plaque, suggesting that screening for carotid plaque might better characterize stroke risk in such patients.
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