Evidence map›Paper›PMID 26861058›Full record

ArticleBMC women's health2016

Mammographic breast density in infertile and parous women.

Meggiorini Maria Letizia, Vestri Anna Rita, De Stefano Maria Grazia, Cipolla Valentina, Bellati Filippo, Maffucci Diana, Nusiner Maria Paola, Aragona Cesare, De Felice Carlo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC women's health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meggiorini Maria LetiziaDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy. marialetizia.meggiorini@uniroma1.it.
Vestri Anna RitaDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
De Stefano Maria GraziaDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
Cipolla ValentinaDepartment of Radiological Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
Bellati FilippoDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
Maffucci DianaDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
Nusiner Maria PaolaDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
Aragona CesareDepartment of Gynecologic-Obstetrical and Urologic Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.
De Felice CarloDepartment of Radiological Sciences, "Sapienza" University of Rome, Viale del Policlinico, 155, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMammographic breast density is a useful marker for breast cancer risk, as breast density is considered one of the strongest breast cancer risk factors. The study objective was to evaluate and compare mammographic breast density in infertile and parous women, as infertility may be associated with high breast density and cancer occurrence.

methodsThis study evaluated mammographic breast density using two different systems, BIRADS and Boyd. A selected patient population of 151 women with primary infertility (case group) was compared to 154 parous women who had at least one previous pregnancy (control group). Both groups were premenopausal women aged ≥ 35.

resultsEvaluation of mammographic features showed that 66.9% of case group patients and 53.9% of control group patients were classified BIRADS-3/BIRADS-4; p < 0.05. Adjusted Odds ratio for the case group in the categories BIRADS-3/BIRADS-4 was 1.78 (95% CI: 1.10-2.89). Using the Boyd classification system, 53.6% of case group patients and 31.8% of control group patients were classified E/F; p < 0.05. Adjusted Odds ratio for case group patients in Boyd categories E/F was 2.05 (95 % CI: 1.07-3.93).

conclusionsBoth systems yielded a higher percentage of increased breast density in the case group. Boyd and BIRADS classification systems indicate to what extend breast cancer lesions may be missed on mammography due to masking by dense tissue. Therefore, patients with a high BIRADS or Boyd score should undergo further investigation.

Indexed as

AdultBreastBreast DensityBreast NeoplasmsFemaleHumansInfertilityMammary Glands, HumanMammographyMass ScreeningMiddle AgedOdds RatioPregnancyRisk Factors

Identifiers

PMID26861058
PMCPMC4748487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.