Evidence map›Paper›PMID 26861032›Full record

SynthesisClinical rheumatology2017

Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis.

M Gaikwad, S Vanlint, M Mittinity, G L Moseley, N Stocks

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Is there role for vitamin D in the treatment of chronic pain?Therapeutic advances in musculoskeletal disease · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M GaikwadDiscipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia. manasi.gaikwad@adelaide.edu.au.
S VanlintDiscipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
M MittinitySchool of Public Health, University of Adelaide, Level 7, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
G L MoseleySansom Institute for Health Research, University of South Australia, Centenary Building C5-7, City East Campus, Adelaide, 5000, Australia.
N StocksDiscipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
University of Adelaide · AUCentenary Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic nonspecific musculoskeletal pain (CNMP) is an idiopathic condition often seen in general practice and rheumatology clinics, the aetiology of which may include vitamin D deficiency. The objective of the present study is to evaluate the effectiveness of vitamin D supplementation in the management of CNMP through a systematic review and meta-analysis. According to PRISMA guidelines, PubMed, Embase, Web of Science, Cochrane and Scopus electronic databases were searched for randomised controlled trials comparing vitamin D supplementation to a control or placebo in CNMP patients; the search was not limited by language or date. Meta-analysis was performed using the mean and standardised mean difference which was computed with 95 % confidence intervals, and overall effect size was calculated. Both fixed and random effects models were used in meta-analysis to account for heterogeneity in the studies. The initial search identified 107 studies, of which 10 were potentially relevant, with 7 studies excluded because they did not meet selection criteria. Three studies were included in the meta-analysis. We found no effect of vitamin D supplementation (standardised mean difference (SMD) 0.004; 95 % confidence interval (CI) -0.248 to 0.256) on pain in CNMP patients. Forest plot is used to present the results from meta-analysis. Contrary to a widespread clinical view, there is a moderate level of evidence that vitamin D supplementation is not helpful for treating CNMP patients.

Indexed as

Chronic DiseaseDietary SupplementsHumansMusculoskeletal PainTreatment OutcomeVitamin DVitaminsVitamin DVitaminsChronic nonspecific musculoskeletal painMeta-analysisSystematic reviewVitamin DVitamin D supplementation

Identifiers

PMID26861032
OpenAlexW2260245112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.