ArticleMucosal immunology2016
Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.
Article in Mucosal immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Mast cells in oral lichen planus and oral lichenoid lesions related to dental amalgam contact.Brazilian oral research · 2024Article
- Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation.EMBO molecular medicine · 2022Article
- Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite-exposed Mice.American journal of respiratory cell and molecular biology · 2022Article
- Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease.Journal of leukocyte biology · 2022Review
- Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma.Frontiers in immunology · 2022Review
- Airway Sensory Nerve Density Is Increased in Chronic Cough.American journal of respiratory and critical care medicine · 2021Article
- Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.Frontiers in physiology · 2021Review
- Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.Journal of translational medicine · 2020Article
- Cytokines and beyond: Regulation of innate immune responses during helminth infection.Cytokine · 2020Review
- IL-5 ExposureAmerican journal of respiratory cell and molecular biology · 2020Article
- Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung.Immunity · 2019Article
- Airway Innervation and Plasticity in Asthma.Physiology (Bethesda, Md.) · 2019Review
- Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights.Clinical reviews in allergy & immunology · 2019Review
- Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Neurotrophins in Asthma.Current allergy and asthma reports · 2018Review
- Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Asthma-like airway inflammation and responses in a rat model of atopic dermatitis induced by neonatal capsaicin treatment.Journal of asthma and allergy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Asthma often progresses from early episodes of insults. How early-life events connect to long-term airway dysfunction remains poorly understood. We demonstrated previously that increased neurotrophin 4 (NT4) levels following early-life allergen exposure cause persistent changes in airway smooth muscle (ASM) innervation and airway hyper-reactivity (AHR) in mice. Herein, we identify pulmonary mast cells as a key source of aberrant NT4 expression following early insults. NT4 is selectively expressed by ASM and mast cells in mice, nonhuman primates, and humans. We show in mice that mast cell-derived NT4 is dispensable for ASM innervation during development. However, upon insults, mast cells expand in number and degranulate to release NT4 and thus become the major source of NT4 under pathological condition. Adoptive transfer of wild-type mast cells, but not NT4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.