ArticleNeurobiology of learning and memory2016
Contextual fear conditioning depresses infralimbic excitability.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Sex differences in contextual fear expression are associated with altered medial prefrontal cortex activity.bioRxiv : the preprint server for biology · 2024Article
- Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain.Neuroscience bulletin · 2024Article
- Conditioning and pseudoconditioning differently change intrinsic excitability of inhibitory interneurons in the neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Influence of Stress Severity on Contextual Fear Extinction and Avoidance in a Posttraumatic-like Mouse Model.Brain sciences · 2024Article
- Global Cerebral Ischemia-induced Depression Accompanies Alteration of Neuronal Excitability in the Infralimbic Cortex Layer 2/3 Pyramidal Neurons.Experimental neurobiology · 2023Article
- Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice.BMC biology · 2023Article
- The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder.Frontiers in neuroscience · 2023Review
- The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages.Experimental neurobiology · 2022Review
- Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits.International journal of molecular sciences · 2022Review
- Editorial: The synaptic basis of neuropathology.Frontiers in synaptic neuroscience · 2022Article
- Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?Neuroscience and biobehavioral reviews · 2021Review
- Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex.Frontiers in synaptic neuroscience · 2021Article
- Infralimbic cortex controls fear memory generalization and susceptibility to extinction during consolidation.Scientific reports · 2020Article
- Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex.Neurobiology of learning and memory · 2020Review
- Repeated Exposure to Multiple Concurrent Stresses Induce Circuit Specific Loss of Inputs to the Posterior Parietal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit.Neurobiology of learning and memory · 2020Review
- Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer's disease, and genetic diversity.Neurobiology of learning and memory · 2019Review
- Prelimbic and infralimbic cortical inactivations attenuate contextually driven discriminative responding for reward.Scientific reports · 2019Article
- Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity.Nature communications · 2018Article
- Neural Activity in Ventral Medial Prefrontal Cortex Is Modulated More Before Approach Than Avoidance During Reinforced and Extinction Trial Blocks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
4 authors.
Funding
Abstract
Patients with posttraumatic stress disorder (PTSD) show hypo-active ventromedial prefrontal cortices (vmPFC) that correlate with their impaired ability to discriminate between safe and dangerous contexts and cues. Previously, we found that auditory fear conditioning depresses the excitability of neurons populating the homologous structure in rodents, the infralimbic cortex (IL). However, it is undetermined if IL depression was mediated by the cued or contextual information. The objective of this study was to examine whether contextual information was sufficient to depress IL neuronal excitability. After exposing rats to context-alone, pseudoconditioning, or contextual fear conditioning, we used whole-cell current-clamp recordings to examine the excitability of IL neurons in prefrontal brain slices. We found that contextual fear conditioning reduced IL neuronal firing in response to depolarizing current steps. In addition, neurons from contextual fear conditioned animals showed increased slow afterhyperpolarization potentials (sAHPs). Moreover, the observed changes in IL excitability correlated with contextual fear expression, suggesting that IL depression may contribute to the encoding of contextual fear.
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