Evidence map›Paper›PMID 26860410›Full record

ArticleMolecular neurobiology2017

Conditioned Medium Derived from Neural Progenitor Cells Induces Long-term Post-ischemic Neuroprotection, Sustained Neurological Recovery, Neurogenesis, and Angiogenesis.

Thorsten R Doeppner, Viktorija Traut, Alexander Heidenreich, Britta Kaltwasser, Bert Bosche, Mathias Bähr, Dirk M Hermann

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Sensorimotor Functional and Structural Networks after Intracerebral Stem Cell Grafts in the Ischemic Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Thorsten R DoeppnerDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany. thorsten.doeppner@uk-essen.de.
Viktorija TrautDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
Alexander HeidenreichDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
Britta KaltwasserDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
Bert BoscheDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
Mathias BährDepartment of Neurology, University of Göttingen Medical School, Göttingen, Germany.
Dirk M HermannDepartment of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
University of Duisburg-Essen · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia and intravenously applied conditioned medium (CM) derived from subventricular zone NPCs. CM dose-dependently reduced infarct volume and brain leukocyte infiltration after 48 h when delivered up to 12 h after focal cerebral ischemia. Neuroprotection persisted in the post-acute stroke phase yielding enhanced neurological recovery that lasted throughout the 28-day observation period. Increased Bcl-2, phosphorylated Akt and phosphorylated STAT-3 abundance, and reduced caspase-3 activity and Bax abundance were noted in ischemic brains of CM-treated mice at 48 h post-stroke, indicative of enhanced cell survival signaling. Long-term neuroprotection was associated with increased brain glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF) concentrations at 28 days resulting in increased neurogenesis and angiogenesis. The observation that NPC-derived CM induces sustained neuroprotection and neurological recovery suggests that cell transplantation may be dispensable when secreted factors are instead administered.

Indexed as

Angiogenesis Inducing AgentsAnimalsBrain IschemiaCells, CulturedCulture Media, ConditionedMaleMiceMice, Inbred C57BLNeural Stem CellsNeurogenesisNeuroprotectionRecovery of FunctionTime FactorsAngiogenesis Inducing AgentsCulture Media, ConditionedCerebral ischemiaConditioned mediumNeural progenitor cellsNeuroregenerationStroke

Identifiers

PMID26860410
OpenAlexW2269332153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.