ArticleBMC cancer2016
Inflammatory biomarker score and cancer: A population-based prospective cohort study.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (Inflammation Latent Variable Methylation Surrogate, InfLaMeS).The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Assessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Disentangling the Complex Relationships Between Autoimmune Diseases and Cancer Through Polygenic Risk Scores: Evidence from a Large Prospective Study.Research square · 2025Article
- Intakes of saturated and unsaturated fat and circulating levels of inflammatory markers among breast cancer survivors.Scientific reports · 2025Article
- Inflammatory score as a predictor of survival and nutritional deterioration in cancer patients: insights from a multicenter cohort study.Frontiers in nutrition · 2025Article
- The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study.BMC cardiovascular disorders · 2024Article
- The mediating role of insulin resistance in the association between inflammatory score and MAFLD: NHANES 2017-2018.Immunity, inflammation and disease · 2024Article
- Associations between inflammatory burden index, prostate cancer, and mortality among middle-aged and elderly individuals.World journal of urology · 2024Article
- Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population.BMC public health · 2024Article
- Granulomatous mastitis masking ductal carcinoma in situ: A case report with literature review.Biomedical reports · 2024Article
- Association of inflammatory score with all-cause and cardiovascular mortality in patients with metabolic syndrome: NHANES longitudinal cohort study.Frontiers in immunology · 2024Article
- An Analysis of Preoperative Inflammatory Indicators That Influence the Drainage Tube Retention Time in Patients with Breast Cancer Surgery.Breast cancer (Dove Medical Press) · 2024Article
- Article
- Mastitis and Risk of Breast Cancer: a Case Control-Retrospective Study and Mini-Review.Maedica · 2022Article
- Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown.Nutrients · 2022Article
- Article
- Article
- Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations.Scientific reports · 2021Article
- Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study.Medicina (Kaunas, Lithuania) · 2020Article
- Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation is associated with cancer but there are conflicting reports on associations of biomarkers of inflammation with cancer risk and mortality. We investigated the associations of C-reactive protein (CRP) and leukocyte count with cancer risk and mortality using individual biomarkers, and an inflammatory score derived from both biomarkers.
methodsWe conducted this analysis among 2,570 men enrolled in the population-based, prospective Kuopio Ischemic Heart Disease Risk Factor Study in Finland. During an average follow-up period of 26 years, 653 cancer cases and 287 cancer deaths occurred. We computed a z-score for each participant, with the combined z-score being the sum of each individual's CRP and leukocyte z-scores. Multivariable-adjusted Cox proportional hazard model was used to evaluate associations with cancer risk and mortality.
resultsUsing individual biomarkers, elevated leukocyte count was associated with an increased risk of cancer (RR = 1.31, 95% CI 1.04-1.66), and cancer mortality (RR=, 95% CI 1.39, 0.98-1.97). The corresponding results for CRP were (RR = 1.23, 95% CI 0.97-1.55) for risk and (RR = 1.15, 95% CI 0.81-1.64) for cancer mortality. Associations of the biomarkers with cancer appeared to be more robust using the combined z-score. HRs comparing men within the highest z-score quartile to those within the lowest z-score quartiles were 1.47 (95% CI 1.16-1.88, p-trend < 0.01) for cancer risk, and 1.48 (95% CI 1.03-2.14, p-trend = 0.09) for cancer mortality.
conclusionOur study suggests that inflammation is associated with cancer risk and mortality, and combining inflammatory biomarkers into a score is a robust method of elucidating this association.
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