Trial reportCancer medicine2016
Associations between advanced cancer patients' survival and family caregiver presence and burden.
Trial report in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04069494 (Descriptors and Predictors of Burden and Information Needs on Symptom Self-management in Thai Patients With Lung Cancer and Their Family Caregivers During Palliative Radiotherapy), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Descriptors and Predictors of Burden and Information Needs on Symptom Self-management in Thai Patients With Lung Cancer and Their Family Caregivers During Palliative Radiotherapy
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effects of Telemedicine on Informal Caregivers of Patients in Palliative Care: Systematic Review and Meta-Analysis.JMIR mHealth and uHealth · 2024Pooled it
- The effectiveness and cost-effectiveness of hospital-based specialist palliative care for adults with advanced illness and their caregivers.The Cochrane database of systematic reviews · 2020Pooled it
- Association between dyadic interventions and outcomes in cancer patients: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.Palliative medicine · 2019Pooled it
- Early palliative care for adults with advanced cancer.The Cochrane database of systematic reviews · 2017Pooled it
- A randomized wait-list controlled trial of a social support intervention for caregivers of patients with primary malignant brain tumor.BMC health services research · 2021Trial
- Associations between advanced cancer patients' survival and family caregiver presence and burden.Cancer medicine · 2016Trial
- The Added Value of Family Caregivers' Level of Mastery in Predicting Survival of Glioblastoma Patients: A Validation Study.Cancer nursingTrial
- The burdens, coping strategies, and unmet needs of family caregivers of Chinese patients with lymphoma receiving commercial CAR-T-cell therapy: A qualitative study.Asia-Pacific journal of oncology nursing · 2026Article
- Participants' Evolving Experiences, Hope, and Coping While Enrolled in a Community-Based Bereavement Support Program: A Pre-Post Mixed-Methods Pilot Study.Current oncology (Toronto, Ont.) · 2026Article
- Outcomes of inpatient chemoradiotherapy for patients with newly diagnosed glioblastoma and significant functional impairment.Neuro-oncology practice · 2026Article
- A process evaluation of early palliative care implementation in the National Cancer Institute Community Oncology Research Program.JNCI cancer spectrum · 2026Article
- Drivers Influencing Prostate Cancer Treatment Decision making - A Qualitative Analysis of Underrepresented Men across the US.Journal of racial and ethnic health disparities · 2025Article
- Low-Tech Telemedicine Reduces Caregiver Burden and Improves Outcomes in Older Adults with Chronic Diseases: Results from a Prospective Study in Romania.Healthcare (Basel, Switzerland) · 2025Article
- Psychological distress interventions for family members in palliative care: a scoping review.BMC palliative care · 2025Article
- Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The role of the caregiver in older patients with advanced prostate cancer: results from the ADHERE Prospective Study of the Meet-URO network.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Spiritual Well-Being and Care Burden in Caregivers of Patients with Breast Cancer in Turkey.Journal of religion and health · 2023Article
- Psychosocial characteristics of patients undergoing cellular immunotherapies and their caregivers across time.Leukemia & lymphoma · 2023Article
- Adaptation of families of adult patients with brain tumor: Partial least squares structural equation modeling.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We conducted a randomized controlled trial (RCT) of an early palliative care intervention (ENABLE: Educate, Nurture, Advise, Before Life Ends) for persons with advanced cancer and their family caregivers. Not all patient participants had a caregiver coparticipant; hence, we explored whether there were relationships between patient survival, having an enrolled caregiver, and caregiver outcomes prior to death. One hundred and twenty-three patient-caregiver dyads and 84 patients without a caregiver coparticipant participated in the ENABLE early versus delayed (12 weeks later) RCT. We collected caregiver quality-of-life (QOL), depression, and burden (objective, stress, and demand) measures every 6 weeks for 24 weeks and every 3 months thereafter until the patient's death or study completion. We conducted survival analyses using log-rank and Cox proportional hazards models. Patients with a caregiver coparticipant had significantly shorter survival (Wald = 4.31, HR = 1.52, CI: 1.02-2.25, P = 0.04). After including caregiver status, marital status (married/unmarried), their interaction, and relevant covariates, caregiver status (Wald = 6.25, HR = 2.62, CI: 1.23-5.59, P = 0.01), being married (Wald = 8.79, HR = 2.92, CI: 1.44-5.91, P = 0.003), and their interaction (Wald = 5.18, HR = 0.35, CI: 0.14-0.87, P = 0.02) were significant predictors of lower patient survival. Lower survival in patients with a caregiver was significantly related to higher caregiver demand burden (Wald = 4.87, CI: 1.01-1.20, P = 0.03) but not caregiver QOL, depression, and objective and stress burden. Advanced cancer patients with caregivers enrolled in a clinical trial had lower survival than patients without caregivers; however, this mortality risk was mostly attributable to higher survival by unmarried patients without caregivers. Higher caregiver demand burden was also associated with decreased patient survival.
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