Evidence map›Paper›PMID 26860118›Full record

SynthesisIrish journal of medical science2016

Metformin versus insulin in gestational diabetes mellitus: a meta-analysis of randomized clinical trials.

B Zhu, L Zhang, Y Y Fan, L Wang, X G Li, T Liu, Y S Cao, Z G Zhao

Registry-linked trialAbstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Irish journal of medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04855513 (Prevention of Pre-eclampsia Using Metformin), which is not on this map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04855513 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial

TypeinterventionalSponsorHamad Medical CorporationRan2022 to 2023Enrolled414ConditionsPreeclampsia, Preeclampsia Severe, High Risk Pregnancy, EclampsiaArmsMetformin
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018
    Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Progress of Clinical Trials for the Treatment of Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

B ZhuBeijing Tian Tan Hospital, Capital Medical University, Beijing, China.
L ZhangBeijing Shijitan Hospital, Capital Medical University, Beijing, China.
Y Y FanBeijing Tongren Hospital, Capital Medical University, Beijing, China.
L WangThe Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
X G LiBeijing Tian Tan Hospital, Capital Medical University, Beijing, China.
T LiuBeijing Tian Tan Hospital, Capital Medical University, Beijing, China.
Y S CaoDong Fang Hospital-The Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
Z G ZhaoBeijing Tian Tan Hospital, Capital Medical University, Beijing, China. 174473712@qq.com.
Beijing Tian Tan Hospital · CNBeijing University of Chinese Medicine · CNBeijing Shijitan Hospital · CNBeijing Tongren Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetformin is widely used in treatment of type 2 diabetes. However, whether it is safe for use in pregnancy is controversial.

methodsA search for relevant studies were performed using PubMed (1948-2014), Embase (1974-2014), the Web of knowledge (1950-2014), and the Cochrane database, included all randomized control trials published in English.

resultsEight RCTs (1712 patients with gestational diabetes mellitus) were retrieved; of those 853 patients were given metformin, and 859 patients were given insulin. Our results showed that metformin does not increase risk of prematurity (RR = 1.26; 95 % CI [0.89, 1.79], P = 0.19). In addition, metformin can either decrease the total weight gain [MD = -1.49, 95 % CI (-2.66, -0.31), P = 0.01] or weight gain after randomization [MD = -1.23, 95 % CI (-1.75, -0.71), P < 0.00001]. No significant differences were observed in patients with pre-eclampsia [RR = 0.82, 95 % CI (0.56, 1.2), P = 0.32] or caesarean section [RR = 0.93, 95 % CI (0.75, 1.16), P = 0.53]. Use of metformin also significantly decreased the risk of neonatal hypoglycemia [RR = 0.58, 95 % CI (0.43, 0.78), P = 0.0003] and admission rates to neonatal intensive care units [RR = 0.74, 95 % CI (0.61, 0.89), P = 0.002]. No other adverse effects were observed, such as hyperbilirubinaemia [RR = 0.83, 95 % CI (0.64, 1.08), P = 0.16], large for gestational age [RR = 0.85, 95 % CI (0.68, 1.05), P = 0.14], small for gestational age [RR = 0.92, 95 % CI (0.61, 1.39), P = 0.69], macrosomia [RR = 0.75, 95 % CI (0.54, 1.03), P = 0.07] or respiratory distress syndrome [RR = 0.88, 95 % CI (0.55, 1.41), P = 0.6].

conclusionsMetformin may be beneficial in treating gestational diabetes. However, even more studies are needed to provide more evidence for the future use of metformin.

Indexed as

Birth WeightCesarean SectionDiabetes, GestationalFemaleGestational AgeHumansInfant, NewbornInsulinMetforminPre-EclampsiaPregnancyRandomized Controlled Trials as TopicInsulinMetforminGestational diabetes mellitusInsulinMetforminRandomized control trials

Identifiers

PMID26860118
OpenAlexW2267211172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.