Evidence map›Paper›PMID 26859881›Full record

SynthesisPloS one2016

Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies.

Yong-Fei Hua, Gao-Qing Wang, Wei Jiang, Jing Huang, Guo-Chong Chen, Cai-De Lu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong-Fei HuaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.
Gao-Qing WangDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.
Wei JiangDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.
Jing HuangDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.
Guo-Chong ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Cai-De LuDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObservational studies inconsistently reported the relationship between vitamin C intake and risk of pancreatic cancer. We conducted a meta-analysis of published case-control and cohort studies to quantify the association.

methodsPotentially eligible studies were found on PubMed and EMBASE databases through May 31, 2015. A random-effects model was assigned to compute summary point estimates with corresponding 95% confidence intervals (CIs). Subgroup and meta-regression analyses were also performed to explore sources of heterogeneity.

resultsOur final analyses included 20 observational studies comprising nearly 5 thousand cases of pancreatic cancer. When comparing the highest with the lowest categories of vitamin C intake, the summary odds ratio/relative risk for case-control studies (14 studies), cohort studies (6 studies) and all studies combined was 0.58 (95% CI: 0.52-0.66), 0.93 (95% CI: 0.78-1.11) and 0.66 (95% CI: 0.58-0.75), respectively. The difference in the findings between case-control and cohort studies was statistically significant (P < .001). Possible publication bias was shown in the meta-analysis of case-control studies.

conclusionThere is insufficient evidence to conclude any relationship between vitamin C intake and risk of pancreatic cancer. The strong inverse association observed in case-control studies may be affected by biases (eg, recall and selection biases) that particularly affect case-control studies and/or potential publication bias. Future prospective studies of vitamin C intake and pancreatic cancer are needed.

Indexed as

AntioxidantsAscorbic AcidCase-Control StudiesCohort StudiesHumansPancreatic NeoplasmsRiskAntioxidantsAscorbic Acid

Identifiers

PMID26859881
PMCPMC4747545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.