ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2016
Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- Effectiveness of bisphosphonate for alleviating tinnitus associated with otosclerosis: a prospective case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy.The Laryngoscope · 2024Article
- Drug selection for inner ear therapy.Frontiers in pharmacology · 2024Article
- Mortui vivos docent: a modern revival of temporal bone plug harvests.Frontiers in neuroscience · 2023Article
- Bisphosphonate therapy in otosclerosis: A scoping review.Laryngoscope investigative otolaryngology · 2022Article
- A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery.MethodsX · 2020Article
- Translating animal models to human therapeutics in noise-induced and age-related hearing loss.Hearing research · 2019Review
- Gene Therapy for Human Sensorineural Hearing Loss.Frontiers in cellular neuroscience · 2019Review
- Third-generation bisphosphonates for cochlear otosclerosis stabilizes sensorineural hearing loss in long-term follow-up.Laryngoscope investigative otolaryngology · 2017Article
- A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection.Journal of visualized experiments : JoVE · 2017Article
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6 authors at 3 institutions in 1 country.
Funding
Abstract
hypothesisDrug delivered to the oval window can diffuse to the apex of the human cochlea.
backgroundWe have previously demonstrated that zoledronate, a nitrogen-containing bisphosphonate, can arrest the sensorineural hearing loss in cochlear otosclerosis. We have also shown that, in animals, delivery of bisphosphonate into the cochlea can dramatically increase delivery efficiency. Intracochlear drug delivery has the potential to increase local concentration of drug while decreasing the risk of systemic toxicity. In the present study, a fluorescently labeled bisphosphonate compound (6-FAM-ZOL) was introduced into the human cochlea through the oval window and its distribution within the temporal bone was quantified.
methodsIn three fresh human temporal bones, we introduced 6-FAM-ZOL via the oval window. We compared these specimens to control specimens treated with artificial perilymph alone. Specimens were then processed, embedded into methyl methacrylate, and ground to the mid-modiolar axis. We quantified the fluorescence in confocal images.
resultsWe found 6-FAM-ZOL to be distributed up to the apical cochlear turn. In specimens treated with 6-FAM-ZOL, we identified a strong baso-apical gradient of fluorescent signal along the lateral cochlear wall and the modiolus both in the scala vestibuli and in the scala tympani.
conclusionBisphosphonate introduced via the oval window in the human cochlea can be delivered up to the apical cochlear turn. Interscalar communication is likely to play an important role in determining patterns of drug delivery in the inner ear.
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