Evidence map›Paper›PMID 26859491›Full record

Trial reportPloS one2016

Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study.

Danni Zheng, Hisatomi Arima, Shoichiro Sato, Antonio Gasparrini, Emma Heeley, Candice Delcourt, Serigne Lo, Yining Huang, Jiguang Wang, Christian Stapf and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00716079 (An International Randomised Controlled Trial to Establish the Effects of Early Intensive Blood Pressure Lowering in Patients With Intracerebral Haemorrhage.), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00716079 nacompletednot on this map

An International Randomised Controlled Trial to Establish the Effects of Early Intensive Blood Pressure Lowering in Patients With Intracerebral Haemorrhage.

TypeinterventionalSponsorThe George InstituteRan2008 to 2012Enrolled2,839ConditionsIntracerebral Hemorrhage, Stroke, HypertensionArmsBlood pressure management policies
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Case-crossover design and its implementation in R.Annals of translational medicine · 2016
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Danni ZhengDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Hisatomi ArimaDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Shoichiro SatoDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Antonio GasparriniDepartment of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Emma HeeleySydney Medical School, the University of Sydney, Sydney, New South Wales, Australia.
Candice DelcourtDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Serigne LoSydney Medical School, the University of Sydney, Sydney, New South Wales, Australia.
Yining HuangDepartment of Neurology, Peking University First Hospital, Beijing, China.
Jiguang WangCentre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Christian StapfDepartment of Neurology, APHP-Hôpital Lariboisière, DHU NeuroVasc Paris-Sorbonne, Université Paris Diderot-Sorbonne Paris Cité, Paris, France.
Thompson RobinsonDepartment of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, United Kingdom.
Pablo LavadosVascular Neurology Program, Neurology Services, Department of Internal Medicine, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.
John ChalmersDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Craig S AndersonDivision of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia.
INTERACT2 investigators

Funding

Medical Research Council MR/M022625/1
6 · The paper itself

Abstract

backgroundRates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.

methodsINTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.

resultsLow ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.

conclusionsExposure to low ambient temperature within several hours increases the risk of ICH.

trial registrationClinicalTrials.gov NCT00716079.

Indexed as

AgedBlood PressureCerebral HemorrhageCold TemperatureFemaleHumansMaleMiddle AgedRisk Factors

Identifiers

PMID26859491
PMCPMC4747478

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.