ArticleCancer cell2016
Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Cancer cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 82 papers.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
82 citing papers in PubMed, 142 citations in OpenAlex.
- Trial
- Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.Blood · 2017Trial
- Article
- PD-1 Expression Promotes Immune Evasion in B-ALL.Hematology reports · 2025Article
- PACLseq: A Standalone Diagnostic Method for Ph-Like Acute Lymphoblastic Leukemia Using Nanopore Sequencing.MedComm · 2025Article
- Frequent TCR rearrangements in pediatric B-cell lymphoblastic acute leukemia: genomic and phenotypic features.Annals of hematology · 2025Article
- Treatment of EPOR-rearranged acute lymphoblastic leukemia with ruxolitinib: case reports and review of the literature.Annals of hematology · 2025Review
- Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q.Blood cancer discovery · 2025Article
- Mechanistic Insights into Tumorigenesis from Serum Proteins.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Review
- B Lineage Acute Lymphoblastic Leukemia with concurrentIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- SJPedPanel: A Pan-Cancer Gene Panel for Childhood Malignancies to Enhance Cancer Monitoring and Early Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Multilineage involvement in KMT2A-rearranged B acute lymphoblastic leukaemia: cell-of-origin, biology, and clinical implications.Histopathology · 2024Article
- Concepts in B cell acute lymphoblastic leukemia pathogenesis.Journal of leukocyte biology · 2024Review
- The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers.Advances in experimental medicine and biology · 2024Review
- Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia.Cell reports · 2023Article
- Article
- Article
- Clinical screening for Ph-like ALL and the developing role of TKIs.Hematology. American Society of Hematology. Education Program · 2022Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 17 institutions in 3 countries.
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yongjin LiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kathryn G RobertsDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Stephanie M DobsonPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Jaeseung C KimDepartment of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.
Debbie Payne-TurnerDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard C HarveyUniversity of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87106, USA.
Marcus ValentineCytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kelly McCastlainDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Donald YergeauDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Laura J JankeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ying ShaoDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
I-Ming L ChenUniversity of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87106, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sasan ZandiPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Steven M KornblauDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Marina KonoplevaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Elias JabbourDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Elisabeth M PaiettaMontefiore Medical Center, Bronx, NY 10467, USA.
Jacob M RoweDepartment of Hematology, Shaare Zedek Medicak Center, Jerusalem 910310, Israel.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Julie Gastier-FosterThe Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Zhaohui GuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shalini ReshmiThe Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Mignon L LohDepartment of Pediatrics and the Helen Diller Family Cancer Center, University of California, San Francisco, CA 94115, USA.
Janis RacevskisDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Martin S TallmanLeukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Peter H WiernikCancer Research Foundation of New York, Bronx, NY 10514, USA.
Mark R LitzowDivision of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
Cheryl L WillmanUniversity of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87106, USA.
John D McPhersonDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John E DickPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Stephen P HungerDepartment of Pediatrics and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: charles.mullighan@stjude.org.
St. Jude Children's Research Hospital · USThe University of Texas MD Anderson Cancer Center · USNationwide Children's Hospital · USUniversity Health Network · CACancer Research Foundation · USChildren's Hospital of Philadelphia · USMemorial Sloan Kettering Cancer Center · USMontefiore Medical Center · USNew Mexico Cancer Center · USPrincess Margaret Cancer Centre · CAShaare Zedek Medical Center · ILUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, Davis · USUniversity of New Mexico · USUniversity of Toronto · CAUNM Comprehensive Cancer CenterWinnMed · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MProject-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6MStatistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO · 2014 to 2026
$111.2MChildren's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5MCOG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LOH, MIGNON LEE-CHEUN, RELLING, MARY V · 2015 to 2019
$15.1MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MCancer and Leukemia Group B - Leukemia Correlative SciencesU10CA101140 · NCI · OHIO STATE UNIVERSITY · PI MARCUCCI, GUIDO · 2003 to 2013
$10.3MNCI NIH HHS CA145707NCI NIH HHS CA180827NCI NIH HHS CA21765NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA021765NCI NIH HHS RC1 CA145707NCI NIH HHS U01 CA157937NCI NIH HHS U10 CA021115NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA101140NCI NIH HHS U10 CA180791NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180827NCI NIH HHS U10 CA98413NCI NIH HHS U10 CA98543NCI NIH HHS U24 CA114737NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196172NCI NIH HHS U24 CA196173NIGMS NIH HHS P50 GM115279
Abstract
Chromosomal rearrangements are a hallmark of acute lymphoblastic leukemia (ALL) and are important ALL initiating events. We describe four different rearrangements of the erythropoietin receptor gene EPOR in Philadelphia chromosome-like (Ph-like) ALL. All of these rearrangements result in truncation of the cytoplasmic tail of EPOR at residues similar to those mutated in primary familial congenital polycythemia, with preservation of the proximal tyrosine essential for receptor activation and loss of distal regulatory residues. This resulted in deregulated EPOR expression, hypersensitivity to erythropoietin stimulation, and heightened JAK-STAT activation. Expression of truncated EPOR in mouse B cell progenitors induced ALL in vivo. Human leukemic cells with EPOR rearrangements were sensitive to JAK-STAT inhibition, suggesting a therapeutic option in high-risk ALL.
Indexed as
Gene OrderAmino Acid SequenceAntineoplastic AgentsBase SequenceHumansMolecular Sequence DataMutationPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, ErythropoietinAntineoplastic AgentsReceptors, Erythropoietin
Identifiers
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Registered trials
NCT00137111ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.