ArticleDevelopmental cell2016
Ancient trans-Acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Mutational analyses of an instability domain reveal its conserved role in the regulation of class-B ARF levels inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- mTACT: A cell type-specific transportome-scale amiRNA toolbox to overcome functional redundancy in Arabidopsis.Plant physiology · 2026Article
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants.Nature plants · 2025Article
- ARGONAUTE10 controls cell fate specification and formative cell divisions in the Arabidopsis root.The EMBO journal · 2024Article
- Conserved and non-conserved RNA-target modules in plants: lessons for a better understanding of Marchantia development.Plant molecular biology · 2023Review
- Protocol: an improved method for inducing sporophyte generation in the model moss Physcomitrium patens under nitrogen starvation.Plant methods · 2023Article
- Clade-D auxin response factors regulate auxin signaling and development in the moss Physcomitrium patens.PLoS biology · 2023Article
- How was apical growth regulated in the ancestral land plant? Insights from the development of non-seed plants.Plant physiology · 2022Review
- CLAVATA modulates auxin homeostasis and transport to regulate stem cell identity and plant shape in a moss.The New phytologist · 2022Article
- Evolution and diversity of the angiosperm anther: trends in function and development.Plant reproduction · 2021Review
- Phytohormone biosynthesis and signaling pathways of mosses.Plant molecular biology · 2021Review
- Genome-wide analysis of plant miRNA action clarifies levels of regulatory dynamics across developmental contexts.Genome research · 2021Article
- Auxin Biology in Bryophyta: A Simple Platform with Versatile Functions.Cold Spring Harbor perspectives in biology · 2021Review
- Studies of moss reproductive development indicate that auxin biosynthesis in apical stem cells may constitute an ancestral function for focal growth control.The New phytologist · 2021Article
- Developmental Genetics of Corolla Tube Formation: Role of the tasiRNA-The Plant cell · 2020Article
- Genetic dissection of the auxin response network.Nature plants · 2020Review
- tasiR-ARFs Production and Target Regulation during In Vitro Maize Plant Regeneration.Plants (Basel, Switzerland) · 2020Article
- Genome-Wide Analysis of Cotton miRNAs During Whitefly Infestation Offers New Insights into Plant-Herbivore Interaction.International journal of molecular sciences · 2019Article
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Abstract
Novel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss Physcomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filamentous protonemal tissue. Through modeling and experimentation, we demonstrate that tasiRNA regulation confers sensitivity and robustness onto the auxin response. Increased auxin sensitivity parallels increased developmental sensitivity to nitrogen, a key environmental signal. We propose that the properties lent to the auxin response network, along with the ability to stochastically modulate development in response to environmental cues, have contributed to repeated cooption of the tasiRNA-ARF module during evolution. The signaling properties of a genetic network, and not just its developmental output, are thus critical to understanding evolution of multicellular forms.
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